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|Title: ||Effect of decaffeination of green and roasted coffees on the in vivo antioxidant activity and prevention of liver injury in rats|
|???metadata.dc.creator???: ||Lima, Adriene R.|
Pereira, Rosemary G. F. A.
Abrahão, Sheila A.
Zangeronimo, Márcio G.
Paula, Fernanda B. A.
Duarte, Stella M. S.
|Keywords: ||Antioxidant activity|
|Publisher: ||Sociedade Brasileira de Farmacognosia|
|Issue Date: ||23-Apr-2013|
|Citation: ||LIMA, A. R. et al. Effect of decaffeination of green and roasted coffees on the in vivo antioxidant activity and prevention of liver injury in rats. Revista Brasileira de Farmacognosia, Curitiba, v. 23, n. 3, p. 506-512, May/Jun. 2013.|
|Abstract: ||Decaffeination and roasting affects the composition of the chlorogenic acids
in coffee, which have antioxidant potential. The aim of this study was to evaluate the
effects of coffee decaffeination on the in vivo antioxidant activity and the prevention
of liver damage. The Wistar rats received intraperitoneal doses of carbon tetrachloride
and daily doses of Arabica coffee brews (whole and decaffeinated, both green and
roasted) by gavage for fi fteen days. The activity of liver marker enzymes aspartate
aminotransferase, alanine aminotransferase and serum albumin were measured as
well as the quantifi cation of the thiobarbituric acid reactive species and the content of
liver total lipids. Aspartate aminotransferase and alanine aminotransferase are good
indicators of liver damage: the results showed that all studied coffee brews decreased
the activity of aspartate aminotransferase and alanine aminotransferase, and liver
levels of thiobarbituric acid reactive species and total lipids. The compounds presents
in coffee brews are able to decrease the hepatic lipid peroxidation induced by carbon
tetrachloride, making a signifi cant hepatoprotective effect, in accordance with the liver
function tests. The coffee brews are hepatoprotective regardless of the decaffeination
process and our results suggest a better protection against liver damage for the roasted
coffee brews compared with green coffee brews.|
|Appears in Collections:||DCA - Artigos publicados em periódicos|
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