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metadata.artigo.dc.title: Analgesic and anti-Inflammatory activities of the 2,8-dihydroxy-1,6-dimethoxyxanthone from Haploclathra paniculata (mart) benth (guttiferae)
metadata.artigo.dc.creator: Moreira, Maria Eliza Castro
Pereira, Rosemary Gualberto Fonseca Alvarenga
Silva, Marcelo Jose Dias
Dias, Danielle Ferreira
Gontijo, Vanessa Silva
Giusti-Paiva, Alexandre
Veloso, Marcia Paranho
Doriguetto, Antônio Carlos
Nagem, Tanus Jorge
Santos, Marcelo Henrique dos
metadata.artigo.dc.subject: Analgesic effect
Anti-inflammatory activity
Oxygenated xanthone
metadata.artigo.dc.publisher: Mary Ann Liebert 12-Jun-2014
metadata.artigo.dc.identifier.citation: MOREIRA, M. E. C. et al. Analgesic and anti-Inflammatory activities of the 2,8-dihydroxy-1,6-dimethoxyxanthone from Haploclathra paniculata (mart) benth (guttiferae). Journal of Medicinal Food, New Rochelle, v. 17, n. 6, p. 686-693, June 2014.
metadata.artigo.dc.description.abstract: In the present study, the pharmacological effects of 2,8-dihydroxy-1,6-dimethoxyxanthone from the bark of Haploclathra paniculata were investigated in mice using in vivo inflammation and nociception models. Acetic acid-induced writhing, paw licking induced by formalin, hot plate, and carrageenan-induced paw edema tests were used to investigate the anti-inflammatory and antinociceptive activities of the xanthone compound. Xanthone, at both doses, inhibited abdominal writhing and the formalin test. At a dose of 20 mg/kg, the time of reaction to the hot plate increased, and significant effects were observed after 30, 60 and 90 min of treatment. At doses of 10 and 20 mg/kg p.o., the 2,8-dihydroxy-1,6-dimethoxyxanthone significantly reduced paw edema at 3 h after the stimulus. The tests also showed no acute toxicity of the xanthone compound in mice. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability was also studied and confirmed the antioxidant activity of the xanthone. To propose the mechanism of action of anti-inflammatory activity of the xanthone, a molecular docking was performed using the isoenzymes cyclooxygenase 1 and 2 and the results indicate that the molecule is capable of inhibiting both the enzymes. Therefore, it can be concluded that 2,8-dihydroxy-1,6-dimethoxyxanthone from H. paniculata demonstrates analgesic, anti-inflammatory, and antioxidant activities.
metadata.artigo.dc.language: en_US
Appears in Collections:DCA - Artigos publicados em periódicos

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