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Título : Mechanism of the vasodilator effect of mono-oxygenated xanthones: a structure-activity relationship study
Autor: Diniz, Thiago Frederico
Pereira, Aline Carvalho
Capettini, Luciano
Santos, Marcelo Rodrigues dos
Nagem, Tanus Jorge
Lemos, Virgínia Soares
Côrtes, Steyner de França
Palavras-chave: Xanthones
4-hydroxyxanthone
4-methoxyxanthone
Vasodilation
Ca2+ channels
Nitric oxide
K+ channels
Publicador: Thieme Medical Publishers
Data da publicação: 2013
Referência: DINIZ, T. F. et al. Mechanism of the vasodilator effect of mono-oxygenated xanthones: a structure-activity relationship study. Planta Medica, Stuttgart, v. 79, n. 16, p. 1495-1500, 2013.
Abstract: The present study characterized the mechanisms involved in the vasodilator effect of two mono-oxygenated xanthones, 4-hydroxyxanthone and 4-methoxyxanthone. 9-Xanthenone, the base structure of xanthones, was used for comparison. 4-Hydroxyxanthone and 9-xanthenone induced a concentration-dependent and endothelium-independent vasodilator effect in arteries precontracted with phenylephrine (0.1 µmol · L−1) or KCl (50 mmol · L−1). 4-Methoxyxanthone induced a concentration-dependent vasodilator effect in arteries precontracted with phenylephrine, which was partially endothelium-dependent, and involved production of nitric oxide. In endothelium-denuded arteries precontracted with KCl, the vasodilator effect of 4-methoxyxanthone was abolished. The vasodilator effect of 4-hydroxyxanthone (96.22 ± 2.10 %) and 4-methoxyxanthone (96.57 ± 12.40 %) was significantly higher than observed with 9-xanthenone (53.63 ± 8.31 %). The presence of an oxygenated radical in position 4 made 4-hydroxyxanthone (pIC50 = 4.45 ± 0.07) and 4-methoxyxanthone (pIC50 = 5.04 ± 0.09) more potent as a vasodilator than 9-xanthenone (pIC50 = 3.92 ± 0.16). In addition, 4-methoxyxanthone was more potent than the other two xanthones. Ca2+ transients in vascular smooth muscle cells elicited by high K+ were abolished by 4-hydroxyxanthone and 9-xanthenone. The endothelium-independent effect of 4-methoxyxanthone was abolished by inhibition of K+ channels by tetraethylammonium. The current work shows that an oxygenated group in position 4 is essential to achieve Emax and to increase the potency of xanthones as vasodilators. Substitution of an OH by OCH3 in position 4 increases the potency of the vasodilator effect and changes the underling mechanism of action from the blockade of L-type calcium channels to an increase in NO production and activation of K+ channels.
URI: https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0033-1350803.pdf
http://repositorio.ufla.br/jspui/handle/1/11722
Idioma: en_US
Aparece nas coleções:DSA - Artigos publicados em periódicos

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