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Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/12068

Title: Histological and immunohistochemical characterization of the inflammatory and glial cells in the central nervous system of goat fetuses and adult male goats naturally infected with Neospora caninum
???metadata.dc.creator???: Costa, Rafael Carneiro
Orlando, Débora Ribeiro
Abreu, Camila Costa
Nakagaki, Karen Yumi Ribeiro
Mesquita, Leonardo Pereira
Nascimento, Lismara Castro
Silva, Aline Costa
Maiorka, Paulo César
Peconick, Ana Paula
Raymundo, Djeison Lutier
Varaschin, Mary Suzan
Keywords: Abortion
Encephalitis
Neosporosis
Publisher: BioMed Central
Issue Date: 2014
Citation: COSTA, R. C. et al. Histological and immunohistochemical characterization of the inflammatory and glial cells in the central nervous system of goat fetuses and adult male goats naturally infected with Neospora caninum. BMC Veterinary Research, [S.l.], v. 14, n. 10, Dec. 2014.
Abstract: Neospora caninum is an apicomplexan protozoan that is considered one of the main agents responsible for abortion in ruminants. The lesions found in the central nervous system (CNS) of aborted fetuses show multifocal necrosis, gliosis, and perivascular cuffs of mononuclear cells, but the inflammatory and glial cells have not been immunophenotypically characterized. The lesions in the CNS of infected adult animals have rarely been described. Therefore, in this study, we characterized the lesions, the immunophenotypes of the inflammatory and glial cells and the expression of MHC-II and PCNA in the CNS of goats infected with N. caninum. The CNS of eight aborted fetuses and six adult male goats naturally infected with N. caninum were analyzed with lectin histochemistry (RCA1) and immunohistochemistry (with anti-CD3, −CD79α, −GFAP, −MHC-II, and -PCNA antibodies). All animals were the offspring of dams naturally infected with N. caninum.
URI: https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-014-0291-7
http://repositorio.ufla.br/jspui/handle/1/12068
???metadata.dc.language???: en_US
Appears in Collections:DMV - Artigos publicados em periódicos

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