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metadata.artigo.dc.title: Bayesian reversible-jump for epistasis analysis in genomic studies
metadata.artigo.dc.creator: Balestre, Márcio
Souza Júnior, Cláudio Lopes de
metadata.artigo.dc.subject: Bayesian analysis
Genome-wide studies
metadata.artigo.dc.publisher: BioMed Central 2016
metadata.artigo.dc.identifier.citation: BALESTRE, M.; SOUZA JÚNIOR, C. L. de. Bayesian reversible-jump for epistasis analysis in genomic studies. BMC Genomics, [S.l.], v. 17, n. 1012, 2016.
metadata.artigo.dc.description.abstract: The large amount of data used in genomic analysis has allowed geneticists to achieve some understanding of the genetic architecture of complex traits. Although the information gathered by molecular markers has permitted gains in predictive accuracy and gene discovery, epistatic effects have been ignored based on exhaustive searches requesting estimates of its effects on the whole genome. In this work, we propose the reversible-jump technique to estimate epistasis in the genome without drastically altering the model dimension. To this end, we used a real maize dataset based on 256 F2:3 progenies plus a simulation data set based on 300 F2 individuals. In the simulation scenario, six QTL presenting main effects (additive and dominance) were combined with seven other epistatic effects totaling 13 QTL controlling the trait.
metadata.artigo.dc.language: en_US
Appears in Collections:DES - Artigos publicados em periódicos
DEX - Artigos publicados em periódicos

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