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|Title: ||A BAYESIAN DESIGN TO TEST DOSE-RESPONSE SEQUENTIAL TRIALS USING ISOTONIC REGRESSION|
|Issue Date: ||1-Aug-2017|
|Publisher: ||Editora UFLA - Universidade Federal de Lavras - UFLA|
|Description: ||The present work aims to achieve a dose with a pre-specified toxicity rate in a target population. It proposes, using Bayesian methods and isotonic regression, a sequential design to allow the researchers to update prior information. The theory behind the design is not easily assimilated to non-statisticians. What makes such approach attractive is its reduction to four steps of easy manipulation, without the need of computational effort. Simulation procedures confirm the effectiveness of the proposed methodology.|
|Other Identifiers: ||http://www.biometria.ufla.br/index.php/BBJ/article/view/145|
|Appears in Collections:||REVISTA BRASILEIRA DE BIOMETRIA|
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