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Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/13951

Title: A BAYESIAN DESIGN TO TEST DOSE-RESPONSE SEQUENTIAL TRIALS USING ISOTONIC REGRESSION
Issue Date: 1-Aug-2017
Publisher: Editora UFLA - Universidade Federal de Lavras - UFLA
Description: The present work aims to achieve a dose with a pre-specified toxicity rate in a target population. It proposes, using Bayesian methods and isotonic regression, a sequential design to allow the researchers to update prior information. The theory behind the design is not easily assimilated to non-statisticians. What makes such approach attractive is its reduction to four steps of easy manipulation, without the need of computational effort. Simulation procedures confirm the effectiveness of the proposed methodology.
URI: http://repositorio.ufla.br/jspui/handle/1/13951
Other Identifiers: http://www.biometria.ufla.br/index.php/BBJ/article/view/145
Appears in Collections:REVISTA BRASILEIRA DE BIOMETRIA

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