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dc.creatorNunes, Alexandro Silva-
dc.creatorCampos, Vicente Paulo-
dc.creatorMascarello, Alessandra-
dc.creatorStumpf, Taisa Regina-
dc.creatorChiaradia-Delatorre, Louise Domenghini-
dc.creatorMachado, Alan Rodrigues Teixeira-
dc.creatorSantos Júnior, Helvécio Martins-
dc.creatorYunes, Rosendo Augusto-
dc.creatorNunes, Ricardo José-
dc.creatorOliveira, Denilson Ferreira-
dc.date.accessioned2017-10-11T18:09:29Z-
dc.date.available2017-10-11T18:09:29Z-
dc.identifier.citationNUNES, A. S. et al. Activity of chalcones derived from 2,4,5-trimethoxybenzaldehyde against Meloidogyne exigua and in silico interaction of one chalcone with a putative caffeic acid 3-O-methyltransferase from Meloidogyne incognita. Experimental Parasitology, San Diego, v. 135, n. 4, p. 661-668, Dec. 2013.pt_BR
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0014489413002683?via%3Dihubpt_BR
dc.identifier.urirepositorio.ufla.br/jspui/handle/1/15508-
dc.description.abstractMeloidogyne exigua is a parasitic nematode of plants that causes great losses to coffee farmers. In an effort to develop parasitic controls, 154 chalcones were synthesized and screened for activity against this nematode. The best results were obtained with (2E)-1-(4′-nitrophenyl)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one (6) with a 50% lethal concentration (LC50) of 171 μg/ml against M. exigua second-stage juveniles, in comparison to the commercially-available nematicide carbofuran which had an LC50 of 260 μg/ml under the same conditions. When coffee plants were used, 6 reduced the nematode population to ∼50% of that observed in control plants. To investigate the mechanism of action of 6, an in silico study was carried out, which indicated that 6 may act against M. exigua through inhibition of a putative caffeic acid 3-O-methyltransferase homodimer, the amino acid sequence of which was determined by examining the genome of Meloidogyne incognita.pt_BR
dc.description.urihttp://repositorio.ufla.br/jspui/handle/1/15508-
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceExperimental Parasitologypt_BR
dc.subjectNematicidept_BR
dc.subjectRoot-knot nematodept_BR
dc.subjectMeloidogynept_BR
dc.subjectProtein modelingpt_BR
dc.subjectChalconept_BR
dc.subjectNematicidapt_BR
dc.subjectNematodo de nó de raizpt_BR
dc.subjectModelagem de proteínaspt_BR
dc.titleActivity of chalcones derived from 2,4,5-trimethoxybenzaldehyde against Meloidogyne exigua and in silico interaction of one chalcone with a putative caffeic acid 3-O-methyltransferase from Meloidogyne incognitapt_BR
dc.typeArtigopt_BR
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