Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/28487
metadata.artigo.dc.title: Molecular modeling studies of piperidine derivatives as new acetylcholinesterase inhibitors against neurodegenerative diseases
metadata.artigo.dc.creator: Cunha, Elaine F. F. da
Resende, José E.
França, Tanos C. C.
Gonçalves, Mateus Aquino
Souza, Felipe R. de
Santos-Garcia, Letícia
Ramalho, Teodorico C.
metadata.artigo.dc.subject: Molecular modeling
Acetylcholinesterase inhibitors
Neurodegenerative diseases - Treatment
Modelagem molecular
Inibidores da acetilcolinesterase
Doenças neurodegenerativas - Tratamento
metadata.artigo.dc.publisher: Hindawi Publishing Corporation
metadata.artigo.dc.date.issued: 2013
metadata.artigo.dc.identifier.citation: CUNHA, E. F. F. da et al. Molecular modeling studies of piperidine derivatives as new acetylcholinesterase inhibitors against neurodegenerative diseases. Journal of Chemistry, [S. l.], v. 2013, p. 1-7, 2013.
metadata.artigo.dc.description.abstract: Neurodegenerative disorders are related to the progressive loss of structure or function and, eventually, death of neurons. These processes are responsible for diseases like Parkinson’s, Alzheimer’s, and Huntington’s, and the main molecular target for the drug design against these illnesses today is the enzyme acetylcholinesterase (AChE). Following this line, in the present work, we applied docking techniques to study some piperidine derivative inhibitors of AChE and further propose structures of six new AChE inhibitors as potential new drugs against neurodegenerative disorders. The best inhibitor proposed was submitted to additional molecular dynamics simulations steps.
metadata.artigo.dc.identifier.uri: http://repositorio.ufla.br/jspui/handle/1/28487
metadata.artigo.dc.language: en_US
Appears in Collections:DQI - Artigos publicados em periódicos



This item is licensed under a Creative Commons License Creative Commons