Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/28490
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dc.creatorMatos, Karina Silva-
dc.creatorCunha, Elaine F. F. da-
dc.creatorAbagyan, Ruben-
dc.creatorRamalho, Teodorico C.-
dc.date.accessioned2018-01-26T15:49:04Z-
dc.date.available2018-01-26T15:49:04Z-
dc.date.issued2014-
dc.identifier.citationMATOS, K. S. et al. Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates. Combinatorial Chemistry & High Throughput Screening, [S. l.], v. 17, n. 6, p. 554-564, 2014.pt_BR
dc.identifier.urihttp://www.eurekaselect.com/118968/articlept_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/28490-
dc.description.abstractAcetylcholinesterase (AChE) is responsible for hydrolysis of acetylcholine (ACh), a function, which if disrupted, leads to cholinergic syndrome. Carbamates (CB) and organophosphorus compounds (OP) are AChE inhibitors, toxic and capable of causing severe poisoning or death to exposed individuals. The AChE reactivation is considered the main function of the oximes. In case of poisoning by CB, there is no consistent data in the literature for an oxime reactivation mechanism. In this work, we evaluated the affinity and reactivity of oximes with activity already reported against AChE inhibited by the OP chemical warfare agent ciclosarin, with MmAChE and HsAChE active sites inhibited by the CB pesticide carbofuran. Thus, our theoretical data indicate that HLO-7, BI-6 and K005 compounds may be promising reactivators of AChE inhibited by carbofuran.pt_BR
dc.languageen_USpt_BR
dc.publisherBentham Sciencept_BR
dc.rightsrestrictAccesspt_BR
dc.sourceCombinatorial Chemistry & High Throughput Screeningpt_BR
dc.subjectAcetylcholinesterasept_BR
dc.subjectDocking studiespt_BR
dc.subjectNeurotoxic agentspt_BR
dc.subjectOximespt_BR
dc.subjectAcetilcolinesterasept_BR
dc.subjectEstudos de docagempt_BR
dc.subjectAgentes neurotóxicospt_BR
dc.subjectOximaspt_BR
dc.titleComputational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamatespt_BR
dc.typeArtigopt_BR
Appears in Collections:DQI - Artigos publicados em periódicos

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