Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/29687
Título: Synthesis and characterization of 159Gd-doped hydroxyapatite nanorods for bioapplications as theranostic systems
Palavras-chave: Hydroxyapatite nanorods
Gadolinium
Neutron activation
Theranostic system
Data do documento: Set-2016
Editor: Elsevier
Citação: CIPRESTE, M. F. et al. Synthesis and characterization of 159Gd-doped hydroxyapatite nanorods for bioapplications as theranostic systems. Materials Chemistry and Physics, Lausanne, v. 181, p. 301-311, Sept. 2016.
Resumo: Gadolinium-doped hydroxyapatite (HA-Gd) nanorods have become promisor theranostic nanoparticles for early stage cancers as radioisotope carriers able to act in the treatment and multi-imaging diagnosis by single photon emission computed tomography and magnetic resonance imaging systems. In this work, gadolinium-doped HA nanorods were synthesized aiming the use as theranostic system for osteosarcomas. The as-prepared HA-Gd nanorods were characterized by XRD with Rietveld refinement method, FTIR, XPS, ICP-AES, TEM, SEM, BET and VSM in order to investigate the physical-chemical, morphology, pore size distribution and magnetic properties. Moreover, phosphorous and gadolinium in the HA-Gd sample were activated by neutron capture, in a nuclear reactor, producing 32P and 159Gd radioisotopes, and the surfaces of these nanorods were functionalized with folic acid. The results indicate that Gd3+ are trapped in the HA nanorods crystal net showing great stability of the HA-Gd interaction. Gadolinium provide paramagnetic properties on HA nanorods and structural phosphorous and gadolinium can be activated to induced gamma and beta activity. The well succeeded production of 159Gd-32P-HA makes this material a promisor agent to act as a theranostic system.
URI: https://www.sciencedirect.com/science/article/pii/S0254058416304771
http://repositorio.ufla.br/jspui/handle/1/29687
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