Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/31936
metadata.artigo.dc.title: New cytotoxic furan from the marine sediment-derived fungi Aspergillus niger
metadata.artigo.dc.creator: Uchoa, Paula Karina S.
Pimenta, Antonia T. A.
Braz-Filho, Raimundo
Oliveira, Maria da Conceição F. de
Saraiva, Natália N.
Rodrigues, Barbara S. F.
Pfenning, Ludwig H.
Abreu, Lucas M.
Wilke, Diego V.
Florêncio, Katharine G. D.
Lima, Mary Anne S.
metadata.artigo.dc.subject: Marine-derived fungi
Aspergillus niger
Furan derivative
Cytotoxic activity
Fungos derivados dos marinhos
Derivado de furano
Atividade citotóxica
metadata.artigo.dc.publisher: Taylor & Francis
metadata.artigo.dc.date.issued: 2017
metadata.artigo.dc.identifier.citation: UCHOA, P. K. S. et al. New cytotoxic furan from the marine sediment-derived fungi Aspergillus niger. Natural Product Research, Abingdon, v. 31, n. 22, p. 2599-2603, 2017.
metadata.artigo.dc.description.abstract: A fungal strain of Aspergillus niger was recovered from sediments collected in the Northeast coast of Brazil (Pecém’s offshore port terminal). Cultivation in different growth media yielded a new ester furan derivative, 1, along with malformin A1, malformin C, cyclo (trans-4-hydroxy-L-Pro-L-Leu), cyclo (trans-4-hydroxy-L-Pro-L-Phe), cyclo (L-Pro-L-Leu), cyclo (L-Pro-L-Phe), pseurotin D, pseurotin A, chlovalicin, cyclo (L-Pro-L-Tyr) and cyclo (L-Pro-L-Val). Compound 1 was cytotoxic against HCT-116 cell line, showing IC50 = 2.9 μg/mL (CI 95% from 1.8 to 4.7 μg/mL).
metadata.artigo.dc.identifier.uri: https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1283499?journalCode=gnpl20
http://repositorio.ufla.br/jspui/handle/1/31936
metadata.artigo.dc.language: en_US
Appears in Collections:DFP - Artigos publicados em periódicos

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