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Campo DCValorIdioma
dc.creatorRezende, Danubia Aparecida de Carvalho Selvati-
dc.creatorCardoso, Maria das Graças-
dc.creatorSouza, Rafaela Vieira-
dc.creatorTeixeira, Maria Luisa-
dc.creatorBrandão, Rafaela Magalhães-
dc.creatorFerreira, Vanuzia Rodrigues Fernandes-
dc.creatorNogueira, Jéssica Oliveira e-
dc.creatorMagalhães, Maisa Lamounier-
dc.creatorMarcussi, Silvana-
dc.creatorNelson, David Lee-
dc.date.accessioned2019-01-17T14:54:55Z-
dc.date.available2019-01-17T14:54:55Z-
dc.date.issued2017-08-14-
dc.identifier.citationREZENDE, D. A. de C. S. et al. Essential oils from Mentha piperita, Cymbopogon citratus, Rosmarinus officinalis, Peumus boldus and Foeniculum vulgare: inhibition of phospholipase A2 and cytotoxicity to human erythrocytes. American Journal of Plant Sciences, [S. l.], v. 8, p. 2196-2207, Aug. 2017.pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/32483-
dc.description.abstractThe essential oils from Mentha piperita, Cymbopogon citratus, Rosmarinus officinalis, Peumus boldus and Foeniculum vulgare were extracted by hydrodistillation and characterized and quantified by GC-MS and GC-DIC. The oils induced hemolysis with all the doses evaluated (0.6 to 1.8 μL), and the diameters of the halos varied between 9 and 15 mm. Pre-incubation of P. boldus oil with Bothrops jararacussu venom resulted in potentiation of venom-induced hemolysis (30%) (proteases and phospholipases A2). The essential oil from M. piperita (0.6 μL) inhibited venom-induced hemolysis by 45%, whereas 0.6 μL of R. officinalis oil increased the hemolysis by 20%. For the essential oil from F. vulgare, 100% inhibition of activity (0.6 and 1.2 μL) was observed. The application of C. citratus oil induced hemolysis with all the volumes evaluated. Phospholipase activity induced by the venom was only inhibited (10%) with the 0.6 μL volume of R. officinalis oil. The oils from M. piperita and F. vulgare (1.8 μL) and C. citratus oil (0.6 μL) potentiated the phospholipase activity. The results highlight the need for a broad characterization and regulation of the use of natural products, because they can have therapeutic or toxic actionspt_BR
dc.languageen_USpt_BR
dc.publisherScientific Research Publishingpt_BR
dc.rightsacesso abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceAmerican Journal of Plant Sciencespt_BR
dc.subjectNatural productspt_BR
dc.subjectSnake venomspt_BR
dc.subjectHemolysispt_BR
dc.subjectPharmacological potentialpt_BR
dc.subjectProdutos naturaispt_BR
dc.subjectVenenos de cobrapt_BR
dc.subjectHemólisept_BR
dc.subjectPotencial farmacológicopt_BR
dc.titleEssential oils from Mentha piperita, Cymbopogon citratus, Rosmarinus officinalis, Peumus boldus and Foeniculum vulgare: inhibition of phospholipase A2 and cytotoxicity to human erythrocytespt_BR
dc.typeArtigopt_BR
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