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|metadata.artigo.dc.title:||Aerobic exercise protects from Pseudomonas aeruginosa-induced pneumonia in elderly mice|
|metadata.artigo.dc.creator:||Durigon, Thomas Stravinskas|
Oliveira-Junior, Manoel Carneiro
Angelis, Kátia de
Palma, Renata Kelly da
Guerra, Juliana Moreno
Damaceno-Rodrigues, Nilsa Regina
Caldini, Elia Garcia
Almeida, Francine Maria de
Aquino-Santos, Helida Cristina
Rigonato-Oliveira, Nicole Cristine
Oliveira, Danielle Bruna Leal de
Oliveira, Ana Paula Ligeiro de
Oliveira, Luiz Vicente Franco de
Durigon, Edison Luiz
Hiemstra, Pieter S.
Vieira, Rodolfo P.
Imunologia do exercício
|metadata.artigo.dc.identifier.citation:||DURIGON, T. S. et al. Aerobic exercise protects from Pseudomonas aeruginosa-induced pneumonia in elderly mice. Journal of Innate Immunity, [S. l.], v. 10, p. 279-290, 2018.|
|metadata.artigo.dc.description.abstract:||Background: Pseudomonas aeruginosa (PS) infection results in severe morbidity and mortality, especially in immune-deficient populations. Aerobic exercise (AE) modulates the immune system, but its effects on the outcomes of pulmonary PS infection in elderly mice are unknown. Methods: BALB/c mice (24 weeks old) were randomized to sedentary, exercise (EX), PS, and PS + EX groups for the acute experimental setting, and PS and PS + EX groups for the chronic setting. Low-intensity AE was performed for 5 weeks, 60 min/day; 24 h after the final AE session, mice were inoculated with 5 × 104 colony-forming units (CFU) of PS, and 24 h and 14 days after PS inoculation, mice were studied. Results: AE inhibited PS colonization (p < 0.001) and lung inflammation (total cells, neutrophils, lymphocytes [p < 0.01] in bronchoalveolar lavage [BAL]), with significant differences in BAL levels of IL-1β (p < 0.001), IL-6 (p < 0.01), CXCL1 (p < 0.001), and TNF-α (p < 0.001), as well as parenchymal neutrophils (p < 0.001). AE increased BAL levels of IL-10 and parenchymal (p < 0.001) and epithelial (p < 0.001) IL-10 expression, while epithelial (p < 0.001) and parenchymal (p < 0.001) NF-κB expression was decreased. AE diminished pulmonary lipid peroxidation (p < 0.001) and increased glutathione peroxidase (p < 0.01). Pre-incubation of BEAS-2B with IL-10 inhibited PS-induced epithelial cell expression of TNF-α (p < 0.05), CD40 (p < 0.01), and dichlorodihydrofluorescein diacetate (p < 0.05). Conclusions: AE inhibits PS-induced lung inflammation and bacterial colonization in elderly mice, involving IL-10/NF-κB, and redox signaling.|
|Appears in Collections:||DSA - Artigos publicados em periódicos|
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