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|metadata.artigo.dc.title:||Genotoxic action of naphthenic acids on the fish macrophage cell line, RTS11|
|metadata.artigo.dc.creator:||Trento, Marcus Vinicius Cardoso|
César, Pedro Henrique Souza
Lee, Lucy E.J.
Naphthenic acids (NAs)
RTS11 cell line
|metadata.artigo.dc.identifier.citation:||TRENTO, M. V. C. et al. Genotoxic action of naphthenic acids on the fish macrophage cell line, RTS11. International Journal of Environment and Pollution, [S.l.], v. 63, n.1/2, 2018.|
|metadata.artigo.dc.description.abstract:||Naphthenic acids (NAs) are chemical constituents found in oil sands process-affected waters (OSPW) that are distinctly toxic to biota. They comprise an ill-defined mixture of carboxylic acids implicated in endocrine disruption, acute toxicity, immunotoxicity, tissue malformation and embryotoxicity in several fish species, in addition to being cytotoxic. Recent evidence indicates a possible genotoxic effect and the present study evaluated the genotoxic potential of NAs using the 'comet' assay and the rainbow trout spleen cell line, RTS11. The results provided a genotoxic value (in arbitrary units) two times higher for the NA concentration at 10 μg/mL (≈ 105) relative to the NA at 1 μg/mL (≈ 45). NAs at 10 μg/mL gave a damage index of 45.86% compared to the damage observed with a positive control-hydrogen peroxide, which was 90.66% (evaluated at 100 μM). The data obtained suggest a genotoxic potential for NAs at doses that could occur naturally in OSPW.|
|Appears in Collections:||DQI - Artigos publicados em periódicos|
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