Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/34759
metadata.artigo.dc.title: Snake venom disintegrins: an overview of their interaction with integrins
metadata.artigo.dc.creator: Cesar, Pedro Henrique Souza
Braga, Mariana Aparecida
Trento, Marcus Vinicius Cardoso
Menaldo, Danilo Luccas
Marcussi, Silvana
metadata.artigo.dc.subject: Disintegrins
Hemostasis
Antitumor
Cell specificity
Integrins
Pharmacological applications
metadata.artigo.dc.publisher: Bentham Science Publishers
metadata.artigo.dc.date.issued: 2019
metadata.artigo.dc.identifier.citation: CESAR, P. H. S. et al. Snake venom disintegrins: an overview of their interaction with integrins. Current Drug Targets, [S.l.], v. 20, n. 4, 2019.
metadata.artigo.dc.description.abstract: Disintegrins are non-enzymatic proteins that interfere on cell–cell interactions and signal transduction, contributing to the toxicity of snake venoms and play an essential role in envenomations. Most of their pharmacological and toxic effects are the result of the interaction of these molecules with cell surface ligands, which has been widely described and studied. These proteins may act on platelets, leading to hemorrhage, and may also induce apoptosis and cytotoxicity, which highlights a high pharmacological potential for the development of thrombolytic and antitumor agents. Additionally, these molecules interfere with the functions of integrins by altering various cellular processes such as migration, adhesion and proliferation. This review gathers information on functional characteristics of disintegrins isolated from snake venoms, emphasizing a comprehensive view of the possibility of direct use of these molecules in the development of new drugs, or even indirectly as structural models.
metadata.artigo.dc.identifier.uri: http://www.eurekaselect.com/166527/article
http://repositorio.ufla.br/jspui/handle/1/34759
metadata.artigo.dc.language: en_US
Appears in Collections:DQI - Artigos publicados em periódicos

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