Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/39932
Título: Leptin and leptin receptor polymorphisms, plasma leptin levels and obesity in Tunisian volunteers
Palavras-chave: Leptin levels
LEP
LEPR
Obesity
Tunisian volunteers
Data do documento: Jun-2018
Editor: Wiley
Citação: NESRINE, Z. et al. Leptin and Leptin receptor polymorphisms, plasma leptin levels and obesity in Tunisian volunteers. International Journal of Experimental Pathology, [S.l.], v. 99, n. 3, p. 121-130, June 2018. DOI: 10.1111/iep.12271.
Resumo: Adipose tissue is an important endocrine organ that secretes a number of adipokines, like Leptin (LEP). The aim this study was to investigate the prevalence of single nucleotide polymorphisms in LEP gene (LEP 3′UTR A/C, −2548 G/A) and LEPR (K109R and Q223R) and their association with Leptin level and obesity. We recruited 169 non‐obese (body mass index [BMI] = 24.51‐3.69 kg/m2) and 160 obese (BMI = 36‐4.78 kg/m2) patients. Genotyping was performed using polymerase chain reaction‐restriction fragment length polymorphism, BMI was calculated, and Leptin level was measured by ELISA. Statistical analyses were performed by spss19.0. According to LEP 3′UTR A/C polymorphism, AC and CC genotype carriers had higher Leptin levels than AA genotype carriers, respectively, 31[0.05‐148.8] (P = .008) vs 41[0.05‐111.6] (P = .003). The K109R polymorphism was associated with obesity (P = .025) and seems to significantly decrease the LEP levels (P < .001). Concerning LEP G2548A polymorphism, our results showed that the OR of obesity associated with 2548 AA/GG was 1.87[1.106‐2.78] P = .028 vs 1.41[1.035‐1.85] P = .045 for 223AA/GG polymorphism. In our haplotype analysis, one haplotype seems to be the more protective and one other seems to be the highest risk to obesity. LEP 3′UTR A/C and LEPR K109R polymorphisms were associated with Leptin level and obesity.
URI: https://onlinelibrary.wiley.com/doi/abs/10.1111/iep.12271
http://repositorio.ufla.br/jspui/handle/1/39932
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