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dc.creatorBraga, Mariana Aparecida-
dc.creatorAbreu, Tatiane Silva de-
dc.creatorTrento, Marcus Vinicius Cardoso-
dc.creatorMachado, Gustavo Henrique Andrade-
dc.creatorPereira, Luciana Lopes Silva-
dc.creatorSimão, Anderson Assaid-
dc.creatorMarcussi, Silvana-
dc.identifier.citationBRAGA, M. A. et al. Prospection of enzyme modulators in aqueous and ethanolic extracts of Lippia sidoides leaves: genotoxicity, digestion, inflammation, and hemostasis. Chemistry & Biodiversity, Zurich, v. 16, n. 3, Mar. 2019. DOI: 10.1002/cbdv.201800558pt_BR
dc.description.abstractThe aqueous and ethanolic extracts of Lippia sidoides Cham. were chemically characterized and tested for their action on enzymes involved in processes such as inflammation, blood coagulation, and digestion. Both extracts potentiated the activity of phospholipases A2 present in the venom of Bothrops atrox in 12 % and completely inhibited the hemolysis induced by B. jararacussu and B. moojeni venoms in the proportions between 1 : 0.5 and 1 : 5 (venom/extracts (w/w)). They inhibited the thrombolysis induced by B. moojeni (10 to 25 %), potentiated the thrombolysis induced by the Lachesis muta muta venom (30 to 80 %), prolonged the coagulation time induced by B. moojeni and L. muta muta venoms, and presented antigenotoxic action. Both extracts reduced the activity of α‐glycosidases, the aqueous extract inhibited lipases, and the ethanolic extract inhibited α‐amylases. The results demonstrate the modulatory action of the extracts on proteases, phospholipases, and digestive enzymes. In addition, the rich phenolic composition of these extracts highlights their potential for nutraceutical use.pt_BR
dc.publisherWiley Online Librarypt_BR
dc.sourceChemistry & Biodiversitypt_BR
dc.subjectLippia sidoidespt_BR
dc.subjectMedicinal chemistrypt_BR
dc.subjectPhospholipase inhibitorspt_BR
dc.subjectProteases inhibitorspt_BR
dc.subjectDigestive enzymes inhibitorspt_BR
dc.subjectAntigenotoxic compoundspt_BR
dc.subjectBiological activitypt_BR
dc.subjectQuímica Medicinalpt_BR
dc.subjectInibidores da fosfolipasept_BR
dc.subjectInibidores de proteasespt_BR
dc.subjectInibidores das enzimas digestivaspt_BR
dc.subjectAtividades antigenotóxicaspt_BR
dc.subjectAtividade biológicapt_BR
dc.titleProspection of enzyme modulators in aqueous and ethanolic extracts of Lippia sidoides leaves: genotoxicity, digestion, inflammation, and hemostasispt_BR
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