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Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/40905
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Campo DCValorIdioma
dc.creatorKuca, Kamil-
dc.creatorNepovimova, Eugenie-
dc.creatorWu, Qinghua-
dc.creatorSouza, Felipe Rodrigues de-
dc.creatorRamalho, Teodorico de Castro-
dc.creatorFranca, Tanos Celmar Costa-
dc.creatorMusilek, Kamil-
dc.date.accessioned2020-05-14T16:31:02Z-
dc.date.available2020-05-14T16:31:02Z-
dc.date.issued2019-
dc.identifier.citationKUCA, K. et al. Experimental hydrophilic reactivator: bisoxime with three positive charges. Chemical Papers, [S.l.], v. 73, p. 777-782, 2019.pt_BR
dc.identifier.urihttps://link.springer.com/article/10.1007/s11696-018-0612-6pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/40905-
dc.description.abstractWithin this study, experimental hydrophilic acetylcholinesterase (AChE) reactivator was evaluated in vitro against selected nerve agents (cyclosarin, tabun, sarin, VX agent). High hydrophilicity of the reactivator is caused by the presence of three positive charges in its molecule. Quaternary moiety involved in the connecting chain can influence linker’s interaction with the inner of the AChE. For the detailed description of reactivator-AChE interaction, docking studies were performed on theoretical models constructed from the chrystallographic structure of Mus musculus AChE (MmAChE).pt_BR
dc.languageen_USpt_BR
dc.publisherSpringerpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceChemical Paperspt_BR
dc.subjectReactivatorpt_BR
dc.subjectOximept_BR
dc.subjectNerve agentpt_BR
dc.subjectDocking studypt_BR
dc.titleExperimental hydrophilic reactivator: bisoxime with three positive chargespt_BR
dc.typeArtigopt_BR
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