Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/41022
metadata.artigo.dc.title: Mitochondriotropic action and DNA protection: Interactions between phenolic acids and enzymes
metadata.artigo.dc.creator: Abreu, Tatiane Silva de
Braga, Mariana Aparecida
Simão, Anderson Assaid
Trento, Marcus Vinicius Cardoso
Eleutério, Mateus Willian de Faria
Pereira, Luciana Lopes Silva
Cunha, Elaine Fontes Ferreira da
Marcussi, Silvana
metadata.artigo.dc.subject: Comet assay
Enzymatic inhibitor
Genotoxicity
Phenolic compounds
Snake venom
Succinate dehydrogenase
metadata.artigo.dc.publisher: Wiley
metadata.artigo.dc.date.issued: Jan-2020
metadata.artigo.dc.identifier.citation: ABREU, T. S. de et al. Mitochondriotropic action and DNA protection: Interactions between phenolic acids and enzymes. Journal of Biochemical and Molecular Toxicology, [S.l.], v. 34, n. 1, Jan. 2020.
metadata.artigo.dc.description.abstract: The protective action of caffeic (CA) and syringic (SA) acids on the genotoxicity exercised by snake venoms was investigated in this study. Molecular interactions between phenolic acids and the enzyme succinate dehydrogenase were also explored. In the electrophoresis assay, SA did not inhibit the genotoxicity induced by the venom. However, CA partially inhibited DNA degradation. In the comet assay, SA and CA exerted an inhibitory effect on the venom‐induced fragmentation. Succinate dehydrogenase presented, in computational analyzes, favorable energies to the molecular bond to both the malonic acid and the phenolic compounds evaluated. In the enzymatic activity assays, SA inhibited succinate dehydrogenase and interfered in the interaction of malonic acid. Meanwhile, CA potentiated the inhibition exerted by the malonic acid. The results suggest transient interactions between toxins present in venoms and phenolic acids, mainly by hydrogen interactions, which corroborate with the data from previous works.
metadata.artigo.dc.identifier.uri: https://onlinelibrary.wiley.com/doi/full/10.1002/jbt.22417
http://repositorio.ufla.br/jspui/handle/1/41022
metadata.artigo.dc.language: en_US
Appears in Collections:DQI - Artigos publicados em periódicos

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