Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/41522
Título : A potential role for cyclophosphamide in the mitigation of acute respiratory distress syndrome among patients with SARS-CoV-2
Autor: Revannasiddaiah, Swaroop
Kumar Devadas, Santhosh
Palassery, Rasmi
Kumar Pant, Nirdosh
Maka, Vinayak V.
Palavras-chave: Cyclophosphamide
Regulatory T cells
Treg
Acute Respiratory Distress Syndrome (ARDS)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
COVID-19
Publicador: Elsevier
Data da publicação: Nov-2020
Referência: REVANNASIDDAIAH, S. et al. A potential role for cyclophosphamide in the mitigation of acute respiratory distress syndrome among patients with SARS-CoV-2. Medical Hypotheses, [S.l.], v. 144, Nov. 2020.
Abstract: While humanity struggles to develop a vaccine against SARS-CoV-2, it is imperative that effective and affordable therapeutic strategies be evolved. Since a majority of the SARS-CoV-2 deaths are due to acute respiratory distress syndrome (ARDS), a strategy to mitigate the same could save countless lives. Since SARS-CoV-2 related ARDS has a strong immunological component, many investigators are utilizing monoclonal antibodies against IL-6, TNF-alpha and CCR5. However, targeting a single cytokine with an expensive monoclonal antibody could be a less pragmatic approach. We propose the use of cyclophosphamide as an immunomodulator, given its proven role in various settings including autoimmune diseases, and in the post-haploidentical stem cell transplant. Cyclophosphamide could deplete cytotoxic and effector T cell populations while relatively sparing the regulatory T cells (Tregs). Cyclophosphamide could tip the balance away from the overtly pro-inflammatory and could be a less expensive and effective alternative to the currently investigated monoclonal antibodies.
URI: https://www.sciencedirect.com/science/article/pii/S030698772031063X
http://repositorio.ufla.br/jspui/handle/1/41522
Idioma: en_US
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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