Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/41545
Registro completo de metadados
Campo DCValorIdioma
dc.creatorSeifirad, Soroush-
dc.date.accessioned2020-06-23T14:17:35Z-
dc.date.available2020-06-23T14:17:35Z-
dc.date.issued2020-11-
dc.identifier.citationSEIFIRAD, S. Pirfenidone: a novel hypothetical treatment for COVID-19. Medical Hypotheses, [S.l.], v. 144, Nov. 2020.pt_BR
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0306987720308380pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/41545-
dc.description.abstractCytokine storm, multiorgan failure, and particularly acute respiratory distress syndrome (ARDS) is the leading cause of mortality and morbidity in patients with COVID-19. A fulminant ARDS kills the majority of COVID-19 victims. Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), is a novel anti-fibrotic agent with trivial adverse effects. Pirfenidone is approved for the treatment of Idiopathic Pulmonary Fibrosis (IPF) for patients with mild to moderate disease. Pirfenidone could inhibit apoptosis, downregulate ACE receptors expression, decrease inflammation by several mechanisms and ameliorate oxidative stress and hence protect pneumocytes and other cells from COVID-19 invasion and cytokine storm simultaneously. Based on the pirfenidone mechanism of action and the known pathophysiology of COVID-19, I believe that pirfenidone has the potential for the treatment of COVID-19 patients.pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceMedical Hypothesespt_BR
dc.subjectCOVID-19pt_BR
dc.subjectPirfenidonept_BR
dc.subjectCytokine stormpt_BR
dc.subjectOxidative stresspt_BR
dc.subjectInflammationpt_BR
dc.subjectAngiotensin-converting enzymept_BR
dc.subjectAcute Respiratory Distress Syndrome (ARDS)pt_BR
dc.titlePirfenidone: a novel hypothetical treatment for COVID-19pt_BR
dc.typeArtigopt_BR
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

Arquivos associados a este item:
Não existem arquivos associados a este item.


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.