1. RI UFLA
  2. Faculdade de Ciências da Saúde - FCS
  3. FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)
Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/41700
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Campo DCValorIdioma
dc.creatorLi, Hui-
dc.creatorChen, Kailan-
dc.creatorLiu, Maochang-
dc.creatorXu, Hua-
dc.creatorXu, Qiong-
dc.date.accessioned2020-07-03T17:51:44Z-
dc.date.available2020-07-03T17:51:44Z-
dc.date.issued2020-07-
dc.identifier.citationLI, H. et al. The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia. Journal of Infection, [S.l.], v. 81, n. 1, p. 115-120, July 2020.pt_BR
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0163445320302073pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/41700-
dc.description.abstractObjectives The study was aimed at investigating the characteristics of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus (2019-nCoV) pneumonia. Methods Children with 2019-nCoV pneumonia or with respiratory syncytial virus (RSV) pneumonia were included. Data including lymphocyte subsets and serum cytokines were collected and analyzed. Results 56 patients were included in the study, 40 children with 2019-nCoV pneumonia and 16 children with RSV pneumonia. Compared with children with RSV pneumonia, patients with 2019-nCoV pneumonia had higher count of CD3+8+ lymphocyte, higher percentages of CD3+, CD3+8+ lymphocytes and a lower percentage of CD19+ lymphocyte. The serum IL-10 level was significantly higher in children with RSV pneumonia. One 2019-nCoV pneumonia child who was with an obvious increase of IL-10 developed severe pneumonia. Conclusions Immune response played a very important role in the development of 2019-nCoV pneumonia. The effective CD8+ T cell response might influence the severity of 2019-nCoV pneumonia. The adaptable change in IL-10 level might contribute to the relatively mild pneumonia symptoms in children with 2019-nCoV pneumonia and bacterial co-infection might be a risk factor of severe 2019-nCoV pneumonia.pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceJournal of Infectionpt_BR
dc.subject2019 novel coronavirus pneumoniapt_BR
dc.subjectLymphocyte subsetspt_BR
dc.subjectSerum cytokinespt_BR
dc.subjectChildrenpt_BR
dc.subjectCOVID-19pt_BR
dc.titleThe profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumoniapt_BR
dc.typeArtigopt_BR
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