Please use this identifier to cite or link to this item:
|Title:||Effects of probiotic therapy on metabolic and inflammatory parameters of rats with Ligature‐Induced Periodontitis associated with restraint stress|
|Keywords:||Alveolar bone loss|
Perda óssea alveolar
Ratos - Doenças periodontais
|Publisher:||American Academy of Periodontology|
|Citation:||FOUREAUX, R. de C. et al. Effects of probiotic therapy on metabolic and inflammatory parameters of rats with Ligature‐Induced Periodontitis associated with restraint stress. Journal Of Periodontology, Chicago, v. 85, n. 7, p. 975-983, Jul. 2014.|
|Abstract:||Background: This study evaluates the effects of probiotic therapy (PT) in rats with ligature‐induced periodontitis associated with restraint stress. Methods: Sixty‐four rats were divided into control, stress (STR), probiotic (PROB), periodontal disease (PD), STR‐PROB, STR‐PD, STR‐PROB‐PD, and PROB‐PD groups. The probiotic was added to the drinking water for 44 days. PD was induced by a ligature. In STR groups, the animals were subjected to restraint stress for 2.5 hours per day for 30 days. Results: Rats with PD exhibited increased alveolar bone loss (P <0.05), as well as increased levels of cyclooxygenase‐2, serum C‐terminal telopeptide (CTX), p38 mitogen‐activated protein kinase (p38), and receptor activator of nuclear factor‐κB ligand and decreased levels of osteoprotegerin (OPG). Stressed rats presented high levels of C‐peptide, corticosterone, and glucose (P <0.05). In general, the presence of stress reduced the expression of CTX and p38 (P <0.05). PT reduced alveolar bone loss in unstressed animals. It also decreased expression of CTX and induced increased expression of OPG in unstressed animals with PD. However, PT was not effective in preventing bone loss or altering the expression of inflammatory markers in stressed animals. PT decreased the number of inflammatory cells in the periodontal tissue (P <0.05). Groups with stress and PD showed decreased villous height and crypt depth. Stress seemed to prevent part of the probiotic beneficial effects on the small intestine. Conclusions: Based on the methodology used, PT may reduce tissue breakdown resulting from PD in unstressed rats. The protocol used for restraint stress influenced the immunomodulatory effects of PT in intestinal and periodontal tissues.|
|Appears in Collections:||DME - Artigos publicados em periódicos|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.