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Title: Metabolic and behavioral effects of ractopamine at continuous low levels in rats under stress
Keywords: β-adrenergic agonist
Zootechnical performance
Elevated Plus-Maze Tests
Agonistas adrenérgicos beta-2
Rato - Estresse
Desempenho zootécnico
Teste de labirinto em cruz elevado
Issue Date: 2015
Publisher: Instituto de Tecnologia do Paraná - Tecpar
Citation: LOPES, E. et al. Metabolic and behavioral effects of ractopamine at continuous low levels in rats under stress. Brazilian Archives of Biology and Technology, Curitiba, v. 58, n. 3, p. 406-413, May/Jun. 2015.
Abstract: This study aimed at evaluating the effect of ractopamine (RAC) on metabolism, zootechnical performance, body composition, and behavior in Wistar rats submitted to acute and chronic restrain stress. The oral dose of 5 mg/kg of RAC was administered in periods of 0, 7, 14, 21, and 28 days. The elevated plus-maze test (EPMT) was used for behavioral assessment. Blood, carcass and viscera characteristics were evaluated. Insulin-dependent glucose transporters (GLUT-4) were semi-quantified by Western Blot in epididymal adipocytes. RAC periods associated with chronic stress increased the GLUT-4 protein expression in adipose tissue in a time-dependent manner (P=0.01), i.e., the longer the RAC addition period, the higher the GLUT-4 concentration in chronically stressed animals (0=1.42; 7=1.19; 14=2.03; 21=1.59; 28=2.35). The stress periods combined with RAC increased the time spent in the opened arms of the maze (Chronic stress: 0=10.6; 7=8.7; 14=5.9; 21=12.3; 28=4.0; Acute stress 0=3.1; 7= 4.7; 14=7.5; 21=0.0; 28=2.8) (P=0.04). Chronic (entries on the closed arms [ECA]=3.60) and acute (ECA=3.80) stress reduced locomotive activity in the maze (P=0.03). The results suggested that stress could negatively affect the possible benefits offered by the RAC, mainly impairing the adipose tissue metabolism and behavior in the animals.
Appears in Collections:DEX - Artigos publicados em periódicos

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