Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/43114
Título : COVID-19: Immunology and treatment options
Autor: Felsenstein, Susanna
Herbert, Jenny A.
McNamara, Paul S.
Hedrich, Christian M.
Palavras-chave: COVID-19
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Immunology
Immune modulating treatment
Acute Respiratory Distress Syndrome (ARDS)
Cytokine storm syndrome
Publicador: Elsevier
Data da publicação: Jun-2020
Referência: FELSENSTEIN, S. et al. COVID-19: Immunology and treatment options. Clinical Immunology, [S.l.], v. 215, June 2020.
Abstract: The novel coronavirus SARS-CoV2 causes COVID-19, a pandemic threatening millions. As protective immunity does not exist in humans and the virus is capable of escaping innate immune responses, it can proliferate, unhindered, in primarily infected tissues. Subsequent cell death results in the release of virus particles and intracellular components to the extracellular space, which result in immune cell recruitment, the generation of immune complexes and associated damage. Infection of monocytes/macrophages and/or recruitment of uninfected immune cells can result in massive inflammatory responses later in the disease. Uncontrolled production of pro-inflammatory mediators contributes to ARDS and cytokine storm syndrome. Antiviral agents and immune modulating treatments are currently being trialled. Understanding immune evasion strategies of SARS-CoV2 and the resulting delayed massive immune response will result in the identification of biomarkers that predict outcomes as well as phenotype and disease stage specific treatments that will likely include both antiviral and immune modulating agents.
URI: https://www.sciencedirect.com/science/article/pii/S1521661620303181
http://repositorio.ufla.br/jspui/handle/1/43114
Idioma: en_US
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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