Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/43178
Título : Treatment of COVID-19 with convalescent plasma: lessons from past coronavirus outbreaks
Autor: Wooding, Denise J.
Bach, Horacio
Palavras-chave: Convalescent plasma
Coronavirus
COVID-19
Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Publicador: Elsevier
Data da publicação: Out-2020
Referência: WOODING, D. J.; BACH, H. Treatment of COVID-19 with convalescent plasma: lessons from past coronavirus outbreaks. Clinical Microbiology and Infection, [S.l.], v. 26, n. 10, p. 1436-1446, Oct. 2020.
Abstract: Background There is currently no treatment known to alter the course of coronavirus disease 2019 (COVID-19). Convalescent plasma has been used to treat a number of infections during pandemics, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern respiratory syndrome coronavirus (MERS-CoV) and now severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Objectives To summarize the existing literature and registered clinical trials on the efficacy and safety of convalescent plasma for treating coronaviruses, and discuss issues of feasibility, and donor and patient selection. Sources A review of articles published in PubMed was performed on 13 July 2020 to summarize the currently available evidence in human studies for convalescent plasma as a treatment for coronaviruses. The World Health Organization International Clinical Trials Registry and clinicaltrials.gov were searched to summarize the currently registered randomized clinical trials for convalescent plasma in COVID-19. Content There were sixteen COVID-19, four MERS and five SARS reports describing convalescent plasma use in humans. There were two randomized control trials, both of which were for COVID-19 and were terminated early. Most COVID-19 reports described a potential benefit of convalescent plasma on clinical outcomes in severe or critically ill patients with few immediate adverse events. However, there were a number of limitations, including the concurrent use of antivirals, steroids and other treatments, small sample sizes, lack of randomization or control groups, and short follow-up time. Data from SARS and COVID-19 suggest that earlier administration probably yields better outcomes. The ideal candidates for recipients and donors are not known. Still, experience with previous coronaviruses tells us that antibodies in convalescent patients are probably short-lived. Patients who had more severe disease and who are earlier in their course of recovery may be more likely to have adequate titres. Finally, a number of practical challenges were identified. Implications There is currently no effective treatment for COVID-19, and preliminary trials for convalescent plasma suggest that there may be some benefits. However, research to date is at high risk of bias, and randomized control trials are desperately needed to determine the efficacy and safety of this therapeutic option.
URI: https://www.sciencedirect.com/science/article/pii/S1198743X20304821
http://repositorio.ufla.br/jspui/handle/1/43178
Idioma: en_US
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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