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dc.creatorCesar, Pedro H. S.-
dc.creatorTrento, Marcus V.-
dc.creatorSales, Thais A.-
dc.creatorSimão, Anderson A.-
dc.creatorRamalho, Teodorico C.-
dc.creatorMarcussi, Silvana-
dc.date.accessioned2020-09-25T20:26:19Z-
dc.date.available2020-09-25T20:26:19Z-
dc.date.issued2020-05-
dc.identifier.citationCESAR, P. H. S. et al. Vanillic acid as phospholipase A2 and proteases inhibitor: in vitro and computational analyses. Biotechnology and Applied Biochemistry, [S.I.], v. 68, n. 3, June 2021. DOI: https://doi.org/10.1002/bab.1943.pt_BR
dc.identifier.urihttps://doi.org/10.1002/bab.1943pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/43212-
dc.description.abstractEnzymatic inhibition by natural compounds may represent a valuable adjuvant in snakebite serum therapy. The objective in this work was to evaluate possible in vitro interactions between vanillic acid and enzymes from Bothrops spp. and Crotalus durissus terrificus venoms, and also suggest a theory as how they interact based on molecular docking. Vanillic acid inhibited the phospholipase activity induced by Bothrops alternatus (∼25% inhibition); the caseinolytic activity induced by Bothrops atrox (∼30%), Bothrops jararacussu (∼44%), and C. d. terrificus (∼33%); the fibrinogenolysis induced by B. jararacussu, B. atrox, and C. d. terrificus (100%); the serine protease activity induced by Bothrops moojeni (∼45%) and Bothrops jararaca (∼66%); the hemolytic activity induced by B. moojeni (∼26%); the thrombolysis activity induced by B. atrox (∼30%) and B. jararacussu (∼20%); and the thrombotic activity induced by C. d. terrificus (∼8%). The compound was also capable of delaying the coagulation time in citrated plasma by 60, 35, and 75 Sec, when incubated with B. moojeni, B. atrox, and B. jararaca, respectively. The results obtained expand the possibilities for future pharmaceutical use of vanillic acid, considering the high homology degree among human and snake venom phospholipases A2 and proteases (involved in chronic inflammatory diseases). Also, this compound can be used as adjuvant to improve currently available treatments for ophidism victims.pt_BR
dc.languageenpt_BR
dc.publisherInternational Union of Biochemistry and Molecular Biologypt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceBiotechnology and Applied Biochemistrypt_BR
dc.subjectBioactive compoundspt_BR
dc.subjectComputational biologypt_BR
dc.subjectEnzymept_BR
dc.subjectCompostos bioativospt_BR
dc.subjectBiologia computacionalpt_BR
dc.subjectEnzimaspt_BR
dc.subjectÁcido vanílicopt_BR
dc.titleVanillic acid as phospholipase A2 and proteases inhibitor: in vitro and computational analysespt_BR
dc.typeArtigopt_BR
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