Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/43294
Título : The immune system as a target for therapy of SARS-CoV-2: a systematic review of the current immunotherapies for COVID-19
Autor: Mansourabadi, Amir Hossein
Sadeghalvad, Mona
Mohammadi-Motlagh, Hamid-Reza
Rezaei, Nima
Palavras-chave: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
COVID-19
Coronavirus
Immune system
Immunotherapy
Publicador: Elsevier
Data da publicação: Out-2020
Referência: MANSOURABADI, A. H. et al. The immune system as a target for therapy of SARS-CoV-2: a systematic review of the current immunotherapies for COVID-19. Life Sciences, [S.l.], v. 258, Oct. 2020.
Abstract: Aims The immune response is essential for the control and resolution of viral infections. Following the outbreak of novel coronavirus disease (COVID-19), several immunotherapies were applied to modulate the immune responses of the affected patients. In this review, we aimed to describe the role of the immune system in response to COVID-19. We also provide a systematic review to collate and describe all published reports of the using immunotherapies, including convalescent plasma therapy, monoclonal antibodies, cytokine therapy, mesenchymal stem cell therapy, and intravenous immunoglobulin and their important outcomes in COVID-19 patients. Material and methods A thorough search strategy was applied to identify published research trials in PubMed, Scopus, Medline, and EMBASE from Dec 1, 2019, to May 4, 2020, for studies reporting clinical outcomes of COVID-19 patients treated with immunotherapies along with other standard cares. Key findings From an initial screen of 80 identified studies, 24 studies provided clinical outcome data on the use of immunotherapies for the treatment of COVID-19 patients, including convalescent plasma therapy (33 patients), monoclonal antibodies (55 patients), interferon (31 patients), mesenchymal stem cell therapy (8 patient), and immunoglobulin (63 patients). Except for nine severe patients who died after treatment, most patients were recovered from COVID-19 with improved clinical symptoms and laboratory assessment. Significance Based on the available evidence, it seems that treatment with immunotherapy along with other standard cares could be an effective and safe approach to modulate the immune system and improvement of clinical outcomes.
URI: https://www.sciencedirect.com/science/article/pii/S0024320520309371
http://repositorio.ufla.br/jspui/handle/1/43294
Idioma: en_US
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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