Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/43562
Título : An enlightening role for cytokine storm in coronavirus infection
Autor: Zhao, Zhongyi
Wei, Yinhao
Tao, Chuanmin
Palavras-chave: COVID-19
Coronavirus
SARS-CoV-2
Severe acute respiratory syndrome coronavirus
Inflammatory cytokines
Síndrome respiratória aguda grave coronavírus
Citocinas inflamatórias
Publicador: Elsevier
Data da publicação: 2020
Referência: ZHAO, Z.; WEI, Y.;TAO, C. An enlightening role for cytokine storm in coronavirus infection. Clinical Immunology, Orlando, 108615, 2020. DOI: https://doi.org/10.1016/j.clim.2020.108615.
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Wuhan, China has dispersed rapidly worldwide. Although most patients present with mild fever, cough with varying pulmonary shadows, a significant portion still develops severe respiratory dysfunction. And these severe cases are often associated with manifestations outside the respiratory tract. Currently, it is not difficult to find inflammatory cytokines upregulated in the blood of infected patients. However, some complications in addition to respiratory system with the coronavirus disease 2019 (COVID-19) are impossible to explain or cannot be attributed to virus itself. Thus excessive cytokines and their potentially fatal adverse effects are probably the answer to the multiple organ dysfunctions and growing mortality. This review provides a comprehensive overview of the mechanisms underlying cytokine storm, summarizes its pathophysiology and improves understanding of cytokine storm associated with coronavirus infections by comparing SARS-CoV-2 with severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV).
URI: https://www.sciencedirect.com/science/article/abs/pii/S1521661620307750#!
http://repositorio.ufla.br/jspui/handle/1/43562
Idioma: en_US
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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