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metadata.artigo.dc.title: Enzymes modulation by dried grape pomace from the manufacture of wines and juices
metadata.artigo.dc.creator: Freire, Juliana Mesquita
Barroso, Amanda Ribeiro
Assis, Amanda Araújo de
Texeira, Bruna Helena
Braga, Jonatas Henrique Guimarães
Oliveira, Daniela Aparecida
Braga, Mariana Aparecida
Marcussi, Silvana
metadata.artigo.dc.subject: Grape extracts
Industrial wastes
Phenolic compounds
Protease modulators
Phospholipase A2 modulators
Extratos de uva
Resíduos Industriais
Compostos fenólicos
Moduladores de protease
Moduladores de fosfolipase A2
metadata.artigo.dc.publisher: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2020
metadata.artigo.dc.identifier.citation: FREIRE, J. M. et al. Enzymes modulation by dried grape pomace from the manufacture of wines and juices. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 56, e18467, 2020. DOI: 10.1590/s2175-97902020000118467.
metadata.artigo.dc.description.abstract: The processing of grapes for the manufacture of juices and wines, generates large quantities of by-products rich in metabolites with antioxidant, antimicrobial, anti-inflammatory and cicatrizing activities. The high homology between human enzymes and snake venoms makes the latter valuable laboratory tools for the study of pathophysiological processes. Proteases and phospholipases A2 act in processes related to hemostasis and inflammatory response. Thus, in this work, dried pomace obtained from grape (Isabel, Niagara, Bordô, BRS Violeta and Blend cultivars) processing were evaluated on phospholipase, proteolytic, hemolytic and thrombolytic activities induced by snakes venoms and the content of phenolic compounds and minerals was evaluated. The dried pomace exerted inhibitory and potentiating actions in all analyzed activities. The enzymatic modulators present in the evaluated dried pomace have potential for therapeutic use, although their broad characterization is still necessary, in order to define adequate amounts and formulations to obtain efficacy and safety in their use.
metadata.artigo.dc.language: en_US
Appears in Collections:DQI - Artigos publicados em periódicos

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