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dc.creatorMarques, Tamara Rezende-
dc.creatorBraga, Mariana Aparecida-
dc.creatorCesar, Pedro Henrique Souza-
dc.creatorSouza, Nilton Pereirade-
dc.creatorFráguas, Rodrigo Martins-
dc.creatorOliveira, Daniela Aparecida-
dc.creatorTrento, Marcus Vinicius Cardoso-
dc.creatorMarcussi, Silvana-
dc.identifier.citationMARQUES, T. R. et al. Evaluation of the brazilian functional fruit Morinda citrifolia as phospholipases A2 and proteases modulator. Phytomedicine Plus, [S.l.], v. 1, n. 4, p. 1-5, Nov. 2021. DOI: 10.1016/j.phyplu.2021.100071.pt_BR
dc.description.abstractMorinda citrifolia is a plant widely consumed as food and used in folk medicine. However, there is little scientific information regarding its therapeutic properties. In this study, aqueous extracts from the peel and pulp of M. citrifolia were characterized according to their modulatory action on phospholipases A2 and proteases (involved in hemostasis and inflammation). Bothrops moojeni venom was used for prospecting the effects of extracts on the human organism since there is high homology between the venom and human enzymes. The aqueous extracts pre-incubated with the venom significantly inhibited (12 to 16%) the phospholipase activity, in the different doses evaluated. M. citrifolia aqueous extract obtained from the peel and pulp (obtained without distillation) completely inhibited the venom-induced hemolytic activity. In contrast, the pulp extract (with distillation) reduced the activity up to 37.5%. The peel extract of M. citrifolia significantly inhibited the caseinolytic activity induced by proteases present in the venom (37% up to 56%). The pulp extract (obtained without distillation) inhibited approximately 50% of the thrombolysis induced by hemorrhagic proteases. The inhibition of phospholipases A2, proteases, and lysis of erythrocytes exerted by the extracts demonstrate their anti-inflammatory potential. They also have effects on blood coagulation, platelet aggregation and others processes related to the pathophysiology of hemostasis. Further studies are needed to confirm their potential use as a nutraceutical with preventive activity in inflammatory diseases and disorders of hemostasis.pt_BR
dc.sourcePhytomedicine Pluspt_BR
dc.subjectMedicinal plantspt_BR
dc.subjectNutraceutical propertiespt_BR
dc.subjectPhospholipase inhibitorspt_BR
dc.titleEvaluation of the brazilian functional fruit Morinda citrifolia as phospholipases A2 and proteases modulatorpt_BR
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