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dc.creatorLopes, Priscilla Karla Fernandes-
dc.creatorEngel, Daiane Fátima-
dc.creatorBertolini, Natalia Oliveira-
dc.creatorMartins, Moisés Silvestre de Azevedo-
dc.creatorPereira, Chrystian Araujo-
dc.creatorVelloso, Licio Augusto-
dc.creatorThomasi, Sérgio Scherrer-
dc.creatorMoura, Rodrigo Ferreira de-
dc.identifier.citationLOPES, P. K. F. et al. Behavioral, neuroplasticity and metabolic effects of 7,8-dihydroxy-4-methylcoumarin associated with physical activity in mice. Metabolic Brain Disease, [S.I.], v. 36, p. 2425-2436, Dec. 2021. DOI:
dc.description.abstractThe search for strategies to develop resilience against metabolic and neuropsychiatric disorders has motivated the clinical and experimental assessment of early life interventions such as lifestyle-based and use of unconventional pharmacological compounds. In this study, we assessed the effects of voluntary physical activity and 7,8-Dihydroxy-4-methylcoumarin (DHMC), independently or in combination, over mice physiological and behavioral parameters, adult hippocampal and hypothalamic neurogenesis, and neurotrophic factors expression in the hypothalamus. C57Bl/6J mice were submitted to a 29-day treatment with DHMC and allowed free access to a running wheel. We found that DHMC treatment alone reduced fasting blood glucose levels. Moreover, physical activity showed an anxiolytic effect in the elevated plus maze task and DHMC produced additional anxiolytic behavior, evidenced by reduced activity during the light cycle in the physical activity group. Although we did not find any differences in hypothalamic or hippocampal adult neurogenesis, DHMC increased gene expression levels of VEGF, which was correlated to the reduced fasting glucose levels. In conclusion, our data emphasize the potential of physical activity in reducing development of neuropsychiatric conditions, such as anxiety, and highlights DHMC as an attractive compound to be investigated in future studies addressing neuropsychiatric disorders associated with metabolic conditions.pt_BR
dc.publisherSpringer Naturept_BR
dc.sourceMetabolic Brain Diseasept_BR
dc.subject7,8-Dihydroxy-4-methylcoumarin (DHMC)pt_BR
dc.subjectVascular Endothelial Growth Factor (VEGF)pt_BR
dc.subjectFasting glucosept_BR
dc.subjectPhysical activitypt_BR
dc.subjectGlicemia de jejumpt_BR
dc.subjectAtividade físicapt_BR
dc.titleBehavioral, neuroplasticity and metabolic effects of 7,8-dihydroxy-4-methylcoumarin associated with physical activity in micept_BR
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