Síntese de hexaidroquinolina, hexaidroacridinadiona e 1,4-diidropiridina catalisada por magnetita

Abstract

The development of drugs nowadays is essential for the society's quality of life. Aiming at better results in the prevention and treatment of various diseases, the medicinal and biochemical field of science has concentrated part of its effort towards this end. Hexahydroquinoline derivatives, such as hexahydroquinoline itself, dihydropyridines and hexahydroacridinedione, have shown great medicinal versatility, depending only on some structural changes to alter their function. With the evolution of these studies, it is also necessary to develop other areas, such as the synthesis of organic components. Organic synthesis is in charge of developing the method in which the molecules will be synthesized. The techniques used in synthesis tend to evolve in order to be more efficient, economically and environmentally viable, aiming to reduce the amount of rejects and parallel products produced during the synthesis process. For this, one of the outputs is the multicomponent synthesis, in which only one container is used for the synthesis of the desired molecules. The use of ethanol as a solvent, avoids the use and disposal of organic pollutants that are polluting in nature, does not expose people involved in the production process to potentially dangerous solvents, in addition to reducing the production cost, which makes production on an industrial scale feasible. However, a high reaction time can be cited as a disadvantage for the synthesis of hexahydroquinoline derivatives. For this, a catalyst must be used, such as magnetite, which acts as a heterogeneous catalyst and has magnetic characteristics, which facilitate its removal and subsequent reuse. In the present work, magnetite was used at different concentrations to catalyze the synthesis of the molecules mentioned above, the synthesis yields were evaluated and the product was characterized by nuclear magnetic resonance (NMR). With a maximum yield of 53.63% using 10 mg of catalyst, a 26% increase in yield was obtained in comparison to the syntheses without any catalyst and high purity, showing promissory results for the catalysis of hexahydroquinolines.