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Title: Achyrocline satureioides (Lam.) DC extracts acting as enzyme modulators: digestion, inflammation, and hemostasis
Other Titles: Extratos de Achyrocline satureioides (Lam.) DC atuando como moduladores enzimáticos: digestão, inflamação e hemostasia
Keywords: Comet assay
Proteases inhibitors
Phospholipases inhibitors
Medicinal plants
Toxins as tools
Ensaio cometa
Inibidores de proteases
Inibidores de fosfolipases
Plantas medicinais
Toxinas como ferramentas
Issue Date: Jun-2022
Publisher: Universidade Estadual de Londrina (UEL)
Citation: BRAGA, M. A. et al. Achyrocline satureioides (Lam.) DC extracts acting as enzyme modulators: digestion, inflammation, and hemostasis. Semina: Ciências Biológicas e da Saúde, Londrina, v. 43, n. 1, p. 101-118, jan./jun. 2022. DOI: 10.5433/1679-0367.2022v43n1p101.
Abstract: Achyrocline satureioides is popularly known for its richness in phenolic compounds and medicinal properties (anti-inflammatory, analgesic, and hepatoprotective). The present study aimed at broadening the knowledge about the pharmacological potential exerted by the aqueous and ethanolic extracts of A. satureioides. These extracts were characterized by HPLC and tested for their modulatory action on phospholipases A2 and proteases of snake venoms. In addition, they were tested on the activities of digestive enzymes. Snake venoms were used as tools since they have enzymes with high functional and structural homology to human enzymes. The results demonstrate that the extracts of A. satureioides act as enzymatic inhibitors or potentiators, interfering in processes related to the hemostasis, such as coagulation and thrombus dissolution. In addition, the anti-genotoxic activity and inhibitions exerted on digestive enzymes suggests their potential use in the prevention and/or treatment of several pathologies. New studies could provide information on how the compounds present in the extracts and the different enzymes interact.
Appears in Collections:DQI - Artigos publicados em periódicos

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