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http://repositorio.ufla.br/jspui/handle/1/55454Registro completo de metadados
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.creator | Bezerra, Julia N. | - |
| dc.creator | Spadeto, João Paulo M. | - |
| dc.creator | Daré, Joyce K. | - |
| dc.creator | Almeida, Wanda Pereira | - |
| dc.creator | Freitas, Matheus P. | - |
| dc.creator | Cormanich, Rodrigo A. | - |
| dc.date.accessioned | 2022-11-09T15:31:06Z | - |
| dc.date.available | 2022-11-09T15:31:06Z | - |
| dc.date.issued | 2022-08-03 | - |
| dc.identifier.citation | BEZERRA, J. N. et al. In silico interactions of the components from the Schinus terebinthifolius extract with human Tyrosinase. ChemPlusChem, [S.l.], v. 87, n. 8, p. 1-12, Aug. 2022. DOI: 10.1002/cplu.202200109. | pt_BR |
| dc.identifier.uri | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cplu.202200109 | pt_BR |
| dc.identifier.uri | http://repositorio.ufla.br/jspui/handle/1/55454 | - |
| dc.description.abstract | The anti-tyrosinaseactivityof the leaf extractofSchinusterebinthifolius,also knownas Brazilianpeppertree,was eval-uated using multiplein silicoapproaches,such as molecularhomology,moleculardocking,MM-GBSA,moleculardynamics,MM-PBSA,QSAR, and skin permeabilitypredictions.With thesecomputationaltools, the compoundsthat downregulatetyrosi-nase enzymeactivitycould be evaluated,and more potentmoleculescould be identified.The results indicatedthat variouscompounds,especiallyluteolin,are accountablefor the anti-tyrosinaseactivity ofS. terebinthifolius.For cosmeticapplication,furtherstudieswith luteolinare especiallyrecommended,forhavingpresenteda good performanceboth in theoreticalinhibition(30.92kJmol1) and skin permeability(LogKp=6.62 cm1). | pt_BR |
| dc.language | en_US | pt_BR |
| dc.publisher | Chemistry Europe | pt_BR |
| dc.rights | restrictAccess | pt_BR |
| dc.source | ChemPlusChem | pt_BR |
| dc.subject | Schinus terebinthifolius | pt_BR |
| dc.subject | Brazilian peppertree | pt_BR |
| dc.subject | Luteolin | pt_BR |
| dc.title | In silico interactions of the components from the Schinus terebinthifolius extract with human Tyrosinase | pt_BR |
| dc.type | Artigo | pt_BR |
| Aparece nas coleções: | DQI - Artigos publicados em periódicos | |
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