Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/56922
Título: T-type Ca2+ channels and their relationship with pre-neoplastic and neoplastic lesions in the human breast
Palavras-chave: Breast cancer
Ductal hyperplasia
Carcinoma in situ
T-type voltage-dependent Ca2+ channel
Neoplastic transformation
Data do documento: 2023
Editor: Associação Brasileira de Divulgação Científica
Citação: AGUIAR, F. et al. T-type Ca2+ channels and their relationship with pre-neoplastic and neoplastic lesions in the human breast. Brazilian Journal of Medical and Biological Research, [S.l.], v. 56, 2023.
Resumo: The expression of T-type voltage-dependent Ca2+ channels (Cav3) has been previously observed in breast cancer, but their expression and subcellular localization were not evaluated in pre-neoplastic lesions. Therefore, this work aimed to evaluate protein expression and subcellular localization of T-type channel isoforms in human breast tissue samples. Protein expressions of CaV3.1, CaV3.2, and CaV3.3 were evaluated by immunohistochemistry in breast without alteration, in proliferative non-neoplastic lesions, and in neoplastic ductal epithelial lesions of the human breast. CaV3.1, CaV3.2, and CaV3.3 nuclear expressions were decreased in advanced stages of neoplastic transformation, whereas CaV3.1 and CaV3.2 cytoplasmic expression increased. Also, the decrease in nuclear expression was correlated with an increase in cytoplasmic expression for CaV3.1 isoform. The change in CaV3 protein expression and subcellular localization are consistent with the neoplastic transformation stages of mammary epithelial cells, evident in early neoplastic lesions, such as ductal carcinomas in situ. These results suggest a possible involvement of CaV3 in the carcinogenic processes and could be considered as a potential pharmacological target in new therapies for breast cancer treatment.
URI: http://repositorio.ufla.br/jspui/handle/1/56922
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