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dc.creatorPereira, Luciano J.-
dc.creatorMacari, Soraia-
dc.creatorCoimbra, Cândido C.-
dc.creatorPereira, Thais dos S. F.-
dc.creatorBarrioni, Breno Rocha-
dc.creatorGomez, Ricardo Santiago-
dc.creatorSilva, Tarcília A.-
dc.creatorPaiva, Saul Martins-
dc.date.accessioned2020-09-04T17:21:12Z-
dc.date.accessioned2023-06-27T18:38:16Z-
dc.date.available2020-09-04T17:21:12Z-
dc.date.available2023-06-27T18:38:16Z-
dc.date.issued2020-09-
dc.identifier.citationPEREIRA, L. J. et al. Aerobic and resistance training improve alveolar bone quality and interferes with bone-remodeling during orthodontic tooth movement in mice. Bone, New York, v. 138, 115496, Sept. 2020. DOI: https://doi.org/10.1016/j.bone.2020.115496.pt_BR
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S8756328220302763#!pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/57325-
dc.description.abstractThe direct effects of physical activity on long bones are already recognized. However, little information is available regarding distant osseous sites, such as maxillary bone. We evaluated the influence of physical training on alveolar bone quality, with and without mechanically-induced load during orthodontic tooth movement in mice. Forty-two C57BL/6 mice were divided into sedentary, resistance and aerobic training groups. Training period lasted for eight weeks and mechanical loads (orthodontic tooth movement - OTM) were applied during the last 14 days of training. Both types of training enhanced the quality of maxillary bone, increasing bone mineral density (BMD), trabecular bone volume (BV) and bone volume/total volume ratio (BV/TV). OTM significantly reduced in trained groups. Consistently, the number of osteoblasts increased whereas the number of osteoclasts decreased on the OTM side in trained groups in comparison to the sedentary group. IGF-1, RUNX2 and OPG genes expression were also increased. The RANKL/OPG ratio and IL-6 expression were reduced in the maxillary bone. Similar results were verified in the femoral bone. In line with these findings, physical training resulted in a decrease of osteoclast differentiation from femoral bone marrow; as well as the force required to fracture the tibia of trained animals increased. Physical training also caused EDL muscle hypertrophy and increased expression of IGF-1 and IGF-1/Myostatin ratio in the gastrocnemius muscle, whereas FNDC5 gene expression was similar among groups in femur, but decreased in alveolar bone submitted to OTM. In conclusion, physical training increased bone quality, not only on long bones, but also in a distant site such as the maxilla. Differences were more evident in the course of maxillary mechanical loading. Mechanisms involve systemic and local effects on bone cells and target molecules as RANKL, OPG, IL-6 and IGF-1.pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceBonept_BR
dc.subjectPreclinical studiespt_BR
dc.subjectCytokinespt_BR
dc.subjectBone qualitypt_BR
dc.subjectMaxillary mechanical loadingpt_BR
dc.subjectEstudos pré-clínicospt_BR
dc.subjectCitocinaspt_BR
dc.subjectQualidade ósseapt_BR
dc.subjectCarga mecânica maxilarpt_BR
dc.titleAerobic and resistance training improve alveolar bone quality and interferes with bone-remodeling during orthodontic tooth movement in micept_BR
dc.typeArtigopt_BR
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