Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/57470
Title: Associations of insulin resistance later in lactation on fertility of dairy cows
Keywords: Oocyte competence
Dairy cows - Reproduction
Late lactation
Metabolic disorder
Competência oócito
Vacas leiteiras - Reprodução
Lactação tardia
Desordem metabólica
Issue Date: 1-Jul-2016
Publisher: Elsevier
Citation: BARUSELLI, P. S. et al. Associations of insulin resistance later in lactation on fertility of dairy cows. Theriogenology, Stoneham, v. 86, n. 1, p. 263-269, 1 July 2016.
Abstract: The challenge of getting dairy cows pregnant during early lactation is a well-described, worldwide problem. However, specifically in farms with poor reproductive, nutritional, and environmental conditions/management, a low pregnancy rate during early lactation is followed inevitably by an increased number of nonpregnant cows after 150 days in milk, with even more difficulties to achieve pregnancy. Therefore, several studies were designed to understand and develop strategies to mitigate reduced fertility of cows during late lactation. Experiments were performed under tropical regions to determine metabolic status during lactation and association of stage of lactation on oocyte quality and fertility. Lactating cows with extended days not pregnant (e.g.,>150 days in milk) often had systemic metabolic alterations, including development of peripheral insulin resistance and various oocyte alterations, including reduced expression of genes encoding glucose transport proteins, reduced amounts of mtDNA, increased expression of mitochondria-related genes, and increased expression of apoptosis-related genes. Additionally, in vitro embryo production and pregnancy per AI were lower in late- versus early-lactation cows in some but not all studies. Notwithstanding, when a normal embryo was transferred to a cow in late lactation, the pregnancy per transfer was reasonable, reinforcing the assertion that fertility problems in late-lactation cows may be associated with oocyte quality, fertilization, and/or failure of early embryo development. In conclusion, insulin resistance may reduce oocyte competence and consequently fertility in late-lactation dairy cows.
URI: https://www.sciencedirect.com/science/article/pii/S0093691X16300784?via%3Dihub#!
http://repositorio.ufla.br/jspui/handle/1/57470
Appears in Collections:DMV - Artigos publicados em periódicos

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