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dc.creatorFerreira, Marina G.-
dc.creatorDuarte, Clara G.-
dc.creatorOliveira, Maira S.-
dc.creatorCastro, Karen L. P.-
dc.creatorTeixeira, Maílson S.-
dc.creatorReis, Lílian P. G.-
dc.creatorZambrano, José A.-
dc.creatorKalapothakis, Evanguedes-
dc.creatorMichel, Ana Flávia R. M.-
dc.creatorSoto-Blanco, Benito-
dc.creatorChávez-Olórtegui, Carlos-
dc.creatorMelo, Marília M.-
dc.date.accessioned2019-01-25T17:11:10Z-
dc.date.accessioned2023-06-27T19:39:15Z-
dc.date.available2019-01-25T17:11:10Z-
dc.date.available2023-06-27T19:39:15Z-
dc.date.issued2016-
dc.identifier.citationFERREIRA, M. G. et al. Toxicity of crude and detoxified Tityus serrulatus venom in anti-venom-producing sheep. Journal of Veterinary Science, Suwon, v. 17, n. 4, p. 467-477, 2016.pt_BR
dc.identifier.urihttps://synapse.koreamed.org/DOIx.php?id=10.4142/jvs.2016.17.4.467pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/57689-
dc.description.abstractSpecific anti-venom used to treat scorpion envenomation is usually obtained from horses after hyperimmunization with crude scorpion venom. However, immunized animals often become ill because of the toxic effects of the immunogens used. This study was conducted to evaluate the toxic and immunogenic activities of crude and detoxified Tityus serrulatus (Ts) venom in sheep during the production of anti-scorpionic anti-venom. Sheep were categorized into three groups: G1, control, immunized with buffer only; G2, immunized with crude Ts venom; and G3, immunized with glutaraldehyde-detoxified Ts venom. All animals were subjected to clinical exams and supplementary tests. G2 sheep showed mild clinical changes, but the other groups tolerated the immunization program well. Specific antibodies generated in animals immunized with either Ts crude venom or glutaraldehyde-detoxified Ts venom recognized the crude Ts venom in both assays. To evaluate the lethality neutralization potential of the produced sera, individual serum samples were pre-incubated with Ts crude venom, then subcutaneously injected into mice. Efficient immune protection of 56.3% and 43.8% against Ts crude venom was observed in G2 and G3, respectively. Overall, the results of this study support the use of sheep and glutaraldehyde-detoxified Ts venom for alternative production of specific anti-venom.pt_BR
dc.languageen_USpt_BR
dc.publisherSynapse Journalspt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceJournal of Veterinary Sciencept_BR
dc.subjectTityus serrulatuspt_BR
dc.subjectAnti-venompt_BR
dc.subjectGlutaraldehyde detoxificationpt_BR
dc.subjectAnti venenopt_BR
dc.subjectDesintoxicação de glutaraldeídopt_BR
dc.titleToxicity of crude and detoxified Tityus serrulatus venom in anti-venom-producing sheeppt_BR
dc.typeArtigopt_BR
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