Eficacia de florfenicol para el tratamiento de infeciones por Pasteurela Multocida y Mannheimia Haemolitica en llamas

Abstract

Florfenicol is one of the main antibiotics used in the therapy of bacterial respiratory infections in the clinic of large animals. However, there are no pharmacokinetic / pharmacodynamic (PK/PD) studies evaluating its efficacy in llamas antibiotic therapy. The objective of the present study is to evaluate the effect of treatment of intramuscular 20 mg/kg dose of florfenicol in the treatment of infections caused by P. multocida and M. Haemolitica in llamas. A Monte Carlo simulation was performed to determine efficacy rates. The estimated efficacy rates for P. multocida were 99%; 20% and 1% and according to MICs of strains 0.5; 1 and 2 respectively. While the estimated efficacy rates for M. haemolitica were 100%, 95% and 3% and accordingto MICs of strains 0.5, 1 and 2 respectively. The probability of obtaining the bacteriological cure after treatment decreased significantly for infections caused by bacteria with MICs greater than 0.5ug / ml for P. multocida (p˂0,01) and 1 ug/ml for M. haemolitica (p˂0,01). These results evidenced the need to incorporate in the therapeutic protocol bacteriological isolation, determination of MIC and therapeutic dose optimization according to the susceptibility of strains of P. multocida and M. Haemolitica in order to avoid therapeutic failures and consequently to enhance the development of Bacterial resistance.