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dc.creatorMendonça, Simony Carvalho-
dc.creatorAazza, Smail-
dc.creatorCarvalho, Alexandre Alves de-
dc.creatorSilva, Diogo Mendes da-
dc.creatorOliveira, Nelma de Mello Silva-
dc.creatorPinto, José Eduardo Brasil Pinto-
dc.creatorBertolucci, Suzan Kelly Vilela-
dc.date.accessioned2023-07-24T20:11:54Z-
dc.date.available2023-07-24T20:11:54Z-
dc.date.issued2023-
dc.identifier.citationMENDONÇA, S. C. et al. Biological screening of herbal extracts and essential oil from Plectranthus species: α-amylase and 5-lipoxygenase inhibition and antioxidant and anti-Candida potentials. Brazilian Journal of Pharmaceutical Sciences, [S.l.], v. 59, 2023.pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/58193-
dc.description.abstractThe phenolic compound content, the antioxidant and α-amylase inhibition potentials of different extracts of the Plectranthus amboinicus, P. barbatus and P. ornatus were evaluated. We also evaluated the influence of plant growth and harvest time on the chemical composition of the essential oil (EO) of P. amboinicus, its antioxidant and anti-Candida activities and the α-amylase and lipoxygenase inhibitions. The turbo-extract of P. barbatus showed the greatest phenolic compound content and antioxidant activity. No α-amylase inhibition activity was observed in the analyzed extracts, but the turbo-extraction and refluxing extracts possessed high antioxidant activities. Protected cultivation and morning harvest conditions gave the best antioxidant activities, which was associated to the highest carvacrol content. P. amboinicus EO antioxidant activity could contribute to the reduction of oxidative stress in diabetes. Causal Candida strains of diabetic foot ulcers showed sensitivity to P. amboinicus EO. C. albicans and C. dubliniensis were the most sensitive of the selected Candida strains. Turbo-extracts or refluxing of the three species extracts and the EO of P. amboinicus should be considered as a potential candidate for the management the complications of type 2 diabetes.pt_BR
dc.languageen_USpt_BR
dc.publisherUniversidade de São Paulopt_BR
dc.rightsacesso abertopt_BR
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceBrazilian Journal of Pharmaceutical Sciencespt_BR
dc.subjectPlectranthus amboinicuspt_BR
dc.subjectPlectranthus barbatuspt_BR
dc.subjectPlectranthus ornatuspt_BR
dc.subjectExtraction methodspt_BR
dc.subjectBiological activitiespt_BR
dc.titleBiological screening of herbal extracts and essential oil from Plectranthus species: α-amylase and 5-lipoxygenase inhibition and antioxidant and anti-Candida potentialspt_BR
dc.typeArtigopt_BR
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