1,4-Dihydropyridine derivatives: an overview of synthesis conditions and biological tests

Abstract

1,4-dihydropyridine is a versatile class of compounds with multiple biological activities, thus holding significant pharmacological potential. Recent studies have provided evidence concerning the anticancer, antimicrobial, and anti-inflammatory properties of 1,4-dihydropyridines, as well as their potential in Alzheimer's disease treatment. Therefore, this class of compounds is a promising candidate in studies of drug development and drug discovery. The major derivatives of 1,4-dihydropyridine can be synthesized through one-pot synthesis in many different ways, varying the solvents, catalysts, and experimental conditions. Due to the compound's remarkable potential and ease of production, in this review we aimed to present the biological activities and synthesis methodologies of the main 1,4-dihydropyridine derivatives reported by scientific literature over the past decade.