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Título: Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid
Autor(es): Pôrto, Laura Cristina Jardim
Castro, Carlos Henrique de
Savergnini, Sílvia Silveira Quintão
Santos, Sérgio Henrique Sousa
Ferreira, Adaliene Versiani Matos
Cordeiro, Letícia Maria de Souza
Sousa Sobrinho, Deny Bruce de
Santos, Robson Augusto Souza
Almeida, Alvair Pinto de
Botion, Leida Maria
Assunto: Cardiac metabolism
Isolated perfused heart
Peroxisome proliferator-activated receptor α
Fatty acid oxidation
Glycolytic flux
Lipoprotein lipase
Publicador: Elsevier
Data de publicação: 13-Dez-2011
Referência: PORTO, L. C. J. et al. Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid. Life Sciences, [S.l.], v. 90, n. 13-14, p. 476-483, Apr. 2012.
Abstract: Aims: As cardiac performance is closely related to its energy supply, our study investigated the effect of the orotic acid cardioprotective agent on the pathways of energy supply, in both conditions of normal flow and ischemia. Main methods: Male Wistar rats were fed during nine days with a balanced diet only or supplemented with 1% orotic acid. Key findings: Dietary administration of orotic acid increased the cardiac utilization of fatty acids, activity of the lipoprotein lipase, expression of the gene of peroxisome proliferator-activated receptor α and its target enzymes. In addition, orotic acid increased the myocardial uptake and incorporation of glucose, glycogen content and level of GLUT4, concentration of glycolytic metabolites and lactate production in both experi- mental conditions, baseline and after regional ischemia. Significance: Thus, in orotic acid hearts there was a simultaneous stimulus of fatty acid oxidation and glyco- lytic pathway, reflected in increased energetic content even in pre-ischemia. The analysis of the cardiac con- tractility index showed a positive inotropic effect of orotic acid due, at least in part, to the increased availability of energy. The result allows us to suggest that the metabolic changes induced by orotic acid result in appreciable alterations on myocardial contractile function.
URI: http://www.sciencedirect.com/science/article/pii/S0024320511006035
http://repositorio.ufla.br/jspui/handle/1/9651
Idioma: en
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