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|Title: ||Carbohydrate-enriched diet impairs cardiac performance by decreasing the utilization of fatty acid and glucose|
|???metadata.dc.creator???: ||Pôrto, L. C. J.|
Savergnini, S. S.Q.
Castro, C. H.
Mario, É. G.
Ferreira, A. V.M.
Santos, S. H.S.
Andrade, S. P.
Santos, R. A.S.
Almeida, A. P.
Botion, L. M.
|Keywords: ||Cardiac tissue|
High carbohydrate diet
|Publisher: ||Committee on Publication Ethics (COPE)|
|Issue Date: ||2011|
|Citation: ||PÔRTO, L. C. J. et al. Carbohydrate-enriched diet impairs cardiac performance by decreasing the utilization of fatty acid and glucose. Therapeutic Advances in Cardiovascular Disease, [S.l.], v. 5, n. 1, p. 11-22, Feb. 2011.|
|Abstract: ||Aims: We hypothesized that a high-carbohydrate diet affects the cardiac performance by
interfering in the metabolic steps involved in energy transfer in this organ. To verify this, we
investigated the myocardial utilization of different substrates and contractile function in rats
fed a high-carbohydrate diet, under normal flow and ischemia.
Methods and Results: Male Wistar rats were fed over 9 days with standard (39.5%
carbohydrate, 8% fiber) or high-carbohydrate diet (58% carbohydrate) and, afterwards, their
cardiac function was examined using isolated heart preparations. The high-carbohydrate diet
decreased the activity of the lipoprotein lipase, utilization of fatty acids, expression of the gene
of peroxisome proliferator-activated receptor a and its target enzymes. In addition, decreased
GLUT4 mass, glucose uptake, glycogen content and glycolytic intermediates were also
observed. High-carbohydrate hearts displayed weaker activation of the glycolytic pathway
during ischemia, according to minor production of lactate, in relation to control hearts.
The functional impairment caused by high-carbohydrate diet shown by the decrease in the
ventricular systolic strength, +dT/dt and ÀdT/dt was, at least in part, due to the low availability
of adenosine triphosphate (ATP).
Conclusion: Our data suggest that a high-carbohydrate diet can damage myocardial contractile
function by decreasing the cardiac utilization of glucose and fatty acids and, consequently, the
|Appears in Collections:||DCA - Artigos publicados em periódicos|
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