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|Title: ||Improved Lipid and glucose metabolism in transgenic rats with increased circulating angiotensin-(1-7)|
|???metadata.dc.creator???: ||Santos, S. H. S.|
Braga, J. F.
Mario, E. G.
Pôrto, L. C. J.
Rodrigues- Machado, M. G.
Botion, L. M.
Santos, R. A. S.
|Keywords: ||Angiotensin-(1-7) Mas axis|
|Publisher: ||American Heart Association|
|Issue Date: ||3-Feb-2010|
|Citation: ||SANTOS, S. H. S. et al. Improved Lipid and glucose metabolism in transgenic rats with increased circulating angiotensin-(1-7). Arteriosclerosis, Thrombosis and Vascular Biology, [S.l.], v. 30, n. 5, p. 953-961, May 2010.|
|Abstract: ||Objective—Obesity and diabetes remain among the world’s most pervasive health problems. Although the importance of
angiotensin II for metabolic regulation is well documented, the role of the angiotensin-(1-7)/Mas axis in this process is
poorly understood. The aim of this study was to evaluate the effect of increased angiotensin-(1-7) plasma levels in lipid
and glucose metabolism using transgenic rats that express an angiotensin-(1-7)-releasing fusion protein,
Methods and Results—The increased angiotensin-(1-7) levels in TGR induced enhanced glucose tolerance, insulin
sensitivity, and insulin-stimulated glucose uptake. In addition, TGR presented decreased triglycerides and
cholesterol levels, as well as a significant decrease in abdominal fat mass, despite normal food intake. These
alterations were accompanied by a marked decrease of angiotensinogen expression and increased Akt in adipose
tissue. Furthermore, augmented plasma levels and expression in adipose tissue was observed for adiponectin.
Accordingly, angiotensin-(1-7) stimulation increased adiponectin production by primary adipocyte culture, which
was blocked by the Mas antagonist A779. Circulating insulin and muscle glycogen content were not altered in
Conclusion—These results show that increased circulating angiotensin-(1-7) levels lead to prominent changes in glucose
and lipid metabolism.|
|Appears in Collections:||DCA - Artigos publicados em periódicos|
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