Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/15350
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dc.creatorMota, Jonas da Silva-
dc.creatorLeite, Ana Cristina-
dc.creatorBatista Junior, João Marcos-
dc.creatorLópez, Silvia Noelí-
dc.creatorAmbrósio, Daniela Luz-
dc.creatorPasserini, Gabriela Duó-
dc.creatorKato, Massuo Jorge-
dc.creatorBolzani, Vanderlan da Silva-
dc.creatorCicarelli, Regina Maria Barretto-
dc.creatorFurlan, Maysa-
dc.date.accessioned2017-09-04T18:51:34Z-
dc.date.available2017-09-04T18:51:34Z-
dc.date.issued2009-
dc.identifier.citationMOTA, J. da S. et al. In vitro trypanocidal activity of phenolic derivatives from Peperomia obtusifolia. Planta Medica, Stuttgart, v. 75, n. 6, p. 620-623, 2009.pt_BR
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0029-1185364pt_BR
dc.identifier.urirepositorio.ufla.br/jspui/handle/1/15350-
dc.description.abstractThe trypanocidal activity of crude extracts and fractions from the leaves and stems of Peperomia obtusifolia (Piperaceae) was evaluated in vitro against the epimastigote forms of Trypanosoma cruzi. Bioactivity-guided fractionation of the most active extracts afforded seven known compounds, including three chromanes, two furofuran lignans and two flavone C-diglycosides. The most active compounds were the chromanes peperobtusin A and 3,4-dihydro-5-hydroxy-2,7-dimethyl-8-(2′′-methyl-2′′-butenyl)-2-(4′-methyl-1′,3′-pentadienyl)-2H-1-benzopyran-6-carboxylic acid, with IC50 values of 3.1 µM (almost three times more active than the positive control benznidazole, IC50 10.4 µM) and 27.0 µM, respectively. Cytotoxicity assays using peritoneal murine macrophages indicated that the chromanes were not toxic at the level of the IC50 for trypanocidal activity. This is the first report on the trypanocidal activity besides unspecific cytotoxicity of chromanes from Peperomia species. Additionally it represents the first time isolation of 3,4-dihydro-5-hydroxy-2,7-dimethyl-8-(2′′-methyl-2′′-butenyl)-2-(4′-methyl-1′,3′-pentadienyl)-2H-1-benzopyran-6-carboxylic acid from P. obtusifolia.pt_BR
dc.languageen_USpt_BR
dc.publisherThiemept_BR
dc.rightsrestrictAccesspt_BR
dc.sourcePlanta Medicapt_BR
dc.subjectChromanespt_BR
dc.subjectPeperomia obtusifoliapt_BR
dc.subjectPiperaceaept_BR
dc.subjectTrypanosoma cruzipt_BR
dc.titleIn vitro trypanocidal activity of phenolic derivatives from Peperomia obtusifoliapt_BR
dc.typeArtigopt_BR
Appears in Collections:DQI - Artigos publicados em periódicos

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