Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/15508
metadata.artigo.dc.title: Activity of chalcones derived from 2,4,5-trimethoxybenzaldehyde against Meloidogyne exigua and in silico interaction of one chalcone with a putative caffeic acid 3-O-methyltransferase from Meloidogyne incognita
metadata.artigo.dc.creator: Nunes, Alexandro Silva
Campos, Vicente Paulo
Mascarello, Alessandra
Stumpf, Taisa Regina
Chiaradia-Delatorre, Louise Domenghini
Machado, Alan Rodrigues Teixeira
Santos Júnior, Helvécio Martins
Yunes, Rosendo Augusto
Nunes, Ricardo José
Oliveira, Denilson Ferreira
metadata.artigo.dc.subject: Nematicide
Root-knot nematode
Meloidogyne
Protein modeling
Chalcone
Nematicida
Nematodo de nó de raiz
Modelagem de proteínas
metadata.artigo.dc.publisher: Elsevier
metadata.artigo.dc.identifier.citation: NUNES, A. S. et al. Activity of chalcones derived from 2,4,5-trimethoxybenzaldehyde against Meloidogyne exigua and in silico interaction of one chalcone with a putative caffeic acid 3-O-methyltransferase from Meloidogyne incognita. Experimental Parasitology, San Diego, v. 135, n. 4, p. 661-668, Dec. 2013.
metadata.artigo.dc.description.abstract: Meloidogyne exigua is a parasitic nematode of plants that causes great losses to coffee farmers. In an effort to develop parasitic controls, 154 chalcones were synthesized and screened for activity against this nematode. The best results were obtained with (2E)-1-(4′-nitrophenyl)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one (6) with a 50% lethal concentration (LC50) of 171 μg/ml against M. exigua second-stage juveniles, in comparison to the commercially-available nematicide carbofuran which had an LC50 of 260 μg/ml under the same conditions. When coffee plants were used, 6 reduced the nematode population to ∼50% of that observed in control plants. To investigate the mechanism of action of 6, an in silico study was carried out, which indicated that 6 may act against M. exigua through inhibition of a putative caffeic acid 3-O-methyltransferase homodimer, the amino acid sequence of which was determined by examining the genome of Meloidogyne incognita.
metadata.artigo.dc.identifier.uri: http://www.sciencedirect.com/science/article/pii/S0014489413002683?via%3Dihub
repositorio.ufla.br/jspui/handle/1/15508
metadata.artigo.dc.language: en_US
Appears in Collections:DQI - Artigos publicados em periódicos

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