Please use this identifier to cite or link to this item:
http://repositorio.ufla.br/jspui/handle/1/29205
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Alves, Fernando H. F. | - |
dc.creator | Crestani, Carlos C. | - |
dc.creator | Resstel, Leonardo B. M. | - |
dc.creator | Correa, Fernando M. A. | - |
dc.date.accessioned | 2018-05-15T12:26:29Z | - |
dc.date.available | 2018-05-15T12:26:29Z | - |
dc.date.issued | 2009-05-11 | - |
dc.identifier.citation | ALVES, F. H. F. et al. N-methyl-D-aspartate receptors in the insular cortex modulate baroreflex in unanesthetized rats. Autonomic Neuroscience: Basic and Clinical, New York, v. 147, n. 1-2, p. 56-63, 11 May 2009. | pt_BR |
dc.identifier.uri | http://www.autonomicneuroscience.com/article/S1566-0702(09)00008-3/fulltext | pt_BR |
dc.identifier.uri | http://repositorio.ufla.br/jspui/handle/1/29205 | - |
dc.description.abstract | In the present study, we report the effect of insular cortex (IC) ablation caused by bilateral microinjection of the non-selective synaptic blocker CoCl2 on cardiac baroreflex response in unanesthetized rats as well as the involvement of local glutamatergic neurotransmission. Unilateral (left or right) microinjection of CoCl2 (1 nmol/ 100 nL) did not affect the bradycardiac response to blood pressure increase evoked by intravenous infusion of phenylephrine nor the tachycardiac response to blood pressure decrease caused by intravenous infusion of sodium nitroprusside, 10 min after CoCl2. Bilateral microinjection of CoCl2 into IC decreased the magnitude of reflex bradycardia without affecting tachycardiac responses. Baroreflex activity returned to control values 60 min after CoCl2 microinjection, confirming its reversible effect. Further we studied the possible involvement of IC-glutamatergic neurotransmission in baroreflex modulation. We observed that bilateral microinjection of the selective NMDA receptor antagonist LY235959 (4 nmol/100 nL) into the IC decreased the magnitude of reflex bradycardia without affecting tachycardiac responses. IC treatment with the selective non-NMDA antagonist NBQX (4 nmol/100 nL) did not affect baroreflex activity. The results suggest that synapses within the IC have a tonic excitatory influence on the baroreflex parasympathetic component. Moreover, the present data suggest that local NMDA-receptors are involved in the ICmediated tonic excitatory influence on baroreflex parasympathetic activity. | pt_BR |
dc.language | en_US | pt_BR |
dc.publisher | Elsevier | pt_BR |
dc.rights | restrictAccess | pt_BR |
dc.source | Autonomic Neuroscience: Basic and Clinical | pt_BR |
dc.subject | Prefrontal cortex | pt_BR |
dc.subject | Glutamatergic neurotransmission | pt_BR |
dc.subject | NMDA receptor | pt_BR |
dc.subject | Cardiovascular system | pt_BR |
dc.subject | Baroreflex | pt_BR |
dc.subject | Blood pressure | pt_BR |
dc.subject | Heart rate | pt_BR |
dc.subject | Córtex pré-frontal | pt_BR |
dc.subject | Neurotransmissão glutamatérgica | pt_BR |
dc.subject | Receptor NMDA | pt_BR |
dc.subject | Sistema cardiovascular | pt_BR |
dc.subject | Barorreflexo | pt_BR |
dc.subject | Pressão sanguínea | pt_BR |
dc.subject | Frequência cardíaca | pt_BR |
dc.title | N-methyl-D-aspartate receptors in the insular cortex modulate baroreflex in unanesthetized rats | pt_BR |
dc.type | Artigo | pt_BR |
Appears in Collections: | DME - Artigos publicados em periódicos |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.