Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/29511
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dc.creatorCorrêa, Thiago Domingos-
dc.creatorPereira, Adriano José-
dc.creatorBrandt, Sebastian-
dc.creatorVuda, Madhusudanarao-
dc.creatorDjafarzadeh, Siamak-
dc.creatorTakala, Jukka-
dc.creatorJakob, Stephan Mathias-
dc.date.accessioned2018-06-28T12:24:08Z-
dc.date.available2018-06-28T12:24:08Z-
dc.date.issued2017-05-
dc.identifier.citationCORRÊA, T. D. et al. Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis. Critical Care, [S.l.], v. 21, n. 1, May 2017.pt_BR
dc.identifier.urihttps://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1691-4pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/29511-
dc.description.abstractBackground: a decrease in blood lactate levels (Lac) >10% during the first hours of resuscitation in sepsis is associated with better outcomes, but the mechanisms are unclear. Our objective was to investigate the relationship between the time course of Lac, inflammatory response, and mitochondrial respiration during experimental sepsis. Methods: original data from two previously published studies were reanalyzed. In cohort 1, pigs were randomized to be resuscitated for 48 h starting at 6, 12, and 24 h, respectively, after fecal peritonitis induction (n = 8 each). Animals were categorized according to the decrease in Lac during the first 6 h of resuscitation (early if ≥10% [Lac ≥10%] or late if <10% or increased [Lac <10%]), and systemic hemodynamics, inflammatory parameters, and mitochondrial function were compared between groups. In a second group of animals with fecal peritonitis and 24 h of resuscitation (n = 16, cohort 2), abdominal regional Lac exchange was measured, and animals were categorized according to the decrease in Lac as in cohort 1. Results: overall mortality was 20% (4 of 20) in the Lac ≥10% group and 60% (12 of 20) in the Lac <10% group (p = 0.022). In cohort 1, systemic hemodynamics were similar in the Lac ≥10% (n = 13) and Lac <10% (n = 11) groups. Plasma interleukin-6 levels increased during unresuscitated sepsis and decreased during resusciation in both groups, but they were lower at study end in the Lac ≥10% group (p = 0.047). Complexes I and II maximal (state 3) and resting (state 4) isolated brain mitochondrial respiration at study end was higher in the Lac ≥10% group than in the Lac <10% group, whereas hepatic, myocardial, and skeletal muscle mitochondrial respiration was similar in both groups. In cohort 2, mesenteric, total hepatic, and renal blood flow at study end was higher in the Lac ≥10% group (n = 7) than in the Lac <10% group (n = 9), despite similar cardiac output. Hepatic lactate influx and uptake in the Lac ≥10% group were approximately 1.5 and 3 times higher, respectively, than in the Lac <10% group (p = 0.066 for both). Conclusions: a decrease in Lac >10% during early resuscitation (6 h) after abdominal sepsis is associated with lower levels of plasma interleukin-6 and improved brain but not hepatic or muscle mitochondrial respiration. Blood flow redistribution to abdominal organs in animals with early decrease in Lac concentrations increases the potential to both deliver and extract Lac.pt_BR
dc.languageen_USpt_BR
dc.publisherBioMed Central (BMC)pt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceCritical Carept_BR
dc.subjectSepsispt_BR
dc.subjectSeptic shockpt_BR
dc.subjectLactate kineticspt_BR
dc.subjectMitochondrial respirationpt_BR
dc.subjectResuscitationpt_BR
dc.subjectCytokinespt_BR
dc.subjectMultiple organ failurept_BR
dc.titleTime course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsispt_BR
dc.typeArtigopt_BR
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