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dc.creatorSantos, Adolfo Luís dos-
dc.creatorChaves-Silva, Samuel-
dc.creatorYang, Lina-
dc.creatorMaia, Lucas Gontijo Silva-
dc.creatorChalfun-Júnior, Antonio-
dc.creatorSinharoy, Senjuti-
dc.creatorZhao, Jian-
dc.creatorBenedito, Vagner Augusto-
dc.date.accessioned2018-08-08T19:06:05Z-
dc.date.available2018-08-08T19:06:05Z-
dc.date.issued2017-10-30-
dc.identifier.citationSANTOS, A. L. dos et al. Global analysis of the MATE gene family of metabolite transporters in tomato. BMC Plant Biology, [S.l.], v. 17, p. 1-13, Oct. 2017.pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/29922-
dc.description.abstractBackground Species in the Solanaceae family are known for producing plethora of specialized metabolites. In addition to biosynthesis pathways, a full comprehension of secondary metabolism must also take into account the transport and subcellular compartmentalization of substances. Here, we examined the MATE (Multidrug and Toxic Compound Extrusion, or Multi-Antimicrobial Extrusion) gene family in the tomato (Solanum lycopersicum) genome with the objective of better understanding the transport of secondary metabolites in this model species. MATE membrane effluxers encompass an ancient gene family of secondary transporters present in all kingdoms of life, but with a remarkable expansion in plants. They mediate the transport of primary and secondary metabolites using the proton motive force through several membrane systems of the cell. Results We identified 67 genes coding for MATE transporters in the tomato genome, 33 of which are expressed constitutively whereas 34 are expressed in specific cell types or environmental conditions. Synteny analyses revealed bona fide paralogs and Arabidopsis orthologs. Co-expression analysis between MATE and regulatory genes revealed 78 positive and 8 negative strong associations (ρ≥|0.8|). We found no evidence of MATE transporters belonging to known metabolic gene clusters in tomato. Conclusions Altogether, our expression data, phylogenetic analyses, and synteny study provide strong evidence of functional homologies between MATE genes of tomato and Arabidopsis thaliana. Our co-expression study revealed potential transcriptional regulators of MATE genes that warrant further investigation. This work sets the stage for genome-wide functional analyses of MATE transporters in tomato and other Solanaceae species of economic relevance.pt_BR
dc.languageen_USpt_BR
dc.publisherBioMed Centralpt_BR
dc.rightsAttribution 4.0 International*
dc.rightsacesso abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceBMC Plant Biologypt_BR
dc.subjectAntiporterpt_BR
dc.subjectEffluxpt_BR
dc.subjectGenome evolutionpt_BR
dc.subjectMetabolic gene clusterpt_BR
dc.subjectRegulatory gene networkpt_BR
dc.titleGlobal analysis of the MATE gene family of metabolite transporters in tomatopt_BR
dc.typeArtigopt_BR
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